Cargando…

Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis

BACKGROUND: Breast cancer is the most fatal malignant cancer among women, the conventional therapeutic modalities of it are limited. Morusin possesses cytotoxicity against some cancer cells in vitro. The purpose of this study is to test the growth inhibition effect of morusin on human breast cancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Haiyan, Wang, Qiaoping, Dong, Lihua, Liu, Chuanlan, Sun, Zhen, Gao, Ling, Wang, Xiujie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634597/ https://www.ncbi.nlm.nih.gov/pubmed/26538209 http://dx.doi.org/10.1186/s13046-015-0252-4

Ejemplares similares

Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition
por: Gao, Ling, et al.
Publicado: (2017)

Mmu-miR-615-3p Regulates Lipoapoptosis by Inhibiting C/EBP Homologous Protein
por: Miyamoto, Yasuhiro, et al.
Publicado: (2014)

TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPARγ2
por: Ho Lee, Jun, et al.
Publicado: (2015)

Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ
por: Zhu, Qi, et al.
Publicado: (2022)

Mechanism of morusin on breast cancer via network pharmacology and in vitro experiments
por: Li, Hangzhen, et al.
Publicado: (2023)

Saturated free fatty acids induce placental trophoblast lipoapoptosis
por: Natarajan, Sathish Kumar, et al.
Publicado: (2021)

Water-Soluble Extract of Pacific Krill Prevents Triglyceride Accumulation in Adipocytes by Suppressing PPARγ and C/EBPα Expression
por: Yamada, Hidetoshi, et al.
Publicado: (2011)

PPARγ and C/EBPα response to acute cold stress in brown adipose tissue
por: Lau, Kin H., et al.
Publicado: (2022)

Laquinimod Prevents Adipogenesis and Obesity by Down-Regulating PPAR-γ and C/EBPα through Activating AMPK
por: Wang, Guang, et al.
Publicado: (2020)

Reduction of Oxidative Stress Attenuates Lipoapoptosis Exacerbated by Hypoxia in Human Hepatocytes
por: Hwang, Sang Youn, et al.
Publicado: (2015)

Kukoamine A inhibits human glioblastoma cell growth and migration through apoptosis induction and epithelial-mesenchymal transition attenuation
por: Wang, Qiaoping, et al.
Publicado: (2016)

The Pro-Health Benefits of Morusin Administration—An Update Review
por: Panek-Krzyśko, Anita, et al.
Publicado: (2021)

Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling
por: Chen, Cunrong, et al.
Publicado: (2019)

Scaffold-Based Pan-Agonist Design for the PPARα, PPARβ and PPARγ Receptors
por: Zhang, Li-Song, et al.
Publicado: (2012)

Centipede grass exerts anti-adipogenic activity through inhibition of C/EBPβ, C/EBPα, and PPARγ expression and the AKT signaling pathway in 3T3-L1 adipocytes
por: Park, Hyoung Joon, et al.
Publicado: (2012)

Morusin Suppresses Cancer Cell Invasion and MMP-2 Expression through ERK Signaling in Human Nasopharyngeal Carcinoma
por: Huang, Cheng-Chen, et al.
Publicado: (2020)

Effects of Morus alba L. and Natural Products Including Morusin on In Vivo Secretion and In Vitro Production of Airway MUC5AC Mucin
por: Lee, Hyun Jae, et al.
Publicado: (2014)

The In Vitro and In Vivo Anti-Inflammatory Effects of a Phthalimide PPAR-γ Agonist
por: Su, Mingzhi, et al.
Publicado: (2017)

Metformin promotes osteogenic differentiation and prevents hyperglycaemia-induced osteoporosis by suppressing PPARγ expression: Metformin prevents osteoporosis by suppressing PPARγ
por: Zheng, Lifeng, et al.
Publicado: (2023)

Prenylated flavonoid morusin protects against TNBS-induced colitis in rats
por: Vochyánová, Zora, et al.
Publicado: (2017)

Formulation, characterization and evaluation of morusin loaded niosomes for potentiation of anticancer therapy
por: Agarwal, Srishti, et al.
Publicado: (2018)

Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway
por: Jia, Yewei, et al.
Publicado: (2020)

Mesonosides A-H, primeverose derivatives from Mesona procumbens suppress adipogenesis by downregulating PPARγ and C/EBPα in 3T3-L1 cells
por: Huang, Hung-Tse, et al.
Publicado: (2021)

Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo
por: Rayner, Melissa L. D., et al.
Publicado: (2022)

Hyperglycemia Changes Expression of Key Adipogenesis Markers (C/EBPα and PPARᵞ)and Morphology of Differentiating Human Visceral Adipocytes
por: Świderska, Ewa, et al.
Publicado: (2019)

Transcriptional Analysis of FOXO1, C/EBP-α and PPAR-γ2 Genes and Their Association with Obesity-Related Insulin Resistance
por: Boughanem, Hatim, et al.
Publicado: (2019)

Derhamnosylmaysin Inhibits Adipogenesis via Inhibiting Expression of PPARγ and C/EBPα in 3T3-L1 Cells
por: Cho, Hang-Hee, et al.
Publicado: (2022)

Isoimperatorin enhances 3T3-L1 preadipocyte differentiation by regulating PPARγ and C/EBPα through the Akt signaling pathway
por: Jiang, Tiantuan, et al.
Publicado: (2019)

Rosiglitazone activation of PPARγ suppresses fractalkine signaling
por: Wan, Yihong, et al.
Publicado: (2010)

Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition
por: Liu, Wei, et al.
Publicado: (2023)

The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of Morus
por: Choi, Dong Wook, et al.
Publicado: (2020)

Prenylated phenolics as promising candidates for combination antibacterial therapy: Morusin and kuwanon G
por: Aelenei, Petruta, et al.
Publicado: (2020)

Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances
por: Hafeez, Amna, et al.
Publicado: (2023)

PPARγ and PPARα synergize to induce robust browning of white fat in vivo
por: Kroon, Tobias, et al.
Publicado: (2020)

Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo
por: Tsukamoto, Tomoko, et al.
Publicado: (2010)

Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites
por: Schmidt, Søren F, et al.
Publicado: (2011)

Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARγ pathways
por: Liang, Yu-Chuan, et al.
Publicado: (2016)

FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis
por: Natarajan, Sathish Kumar, et al.
Publicado: (2017)

Monounsaturated fatty acids protect against palmitate-induced lipoapoptosis in human umbilical vein endothelial cells
por: Lee, Dustin M., et al.
Publicado: (2019)

Protein Phosphatase 4 Promotes Hepatocyte Lipoapoptosis by Regulating RAC1/MLK3/JNK Pathway
por: Huang, Xiuqing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6lpkp6kp8dknqctrkdimo0ilt5