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Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease (disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, significant advances have been made in the elucidation of the ALL-associated processes. Thus, we u...

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Autores principales: Zhang, Cheng, Zhong, Jiang F., Stucky, Andres, Chen, Xue-Lian, Press, Michael F., Zhang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634719/
https://www.ncbi.nlm.nih.gov/pubmed/26543507
http://dx.doi.org/10.1186/s13148-015-0151-8
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author Zhang, Cheng
Zhong, Jiang F.
Stucky, Andres
Chen, Xue-Lian
Press, Michael F.
Zhang, Xi
author_facet Zhang, Cheng
Zhong, Jiang F.
Stucky, Andres
Chen, Xue-Lian
Press, Michael F.
Zhang, Xi
author_sort Zhang, Cheng
collection PubMed
description Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease (disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, significant advances have been made in the elucidation of the ALL-associated processes. Thus, we understand that histone acetylation is involved in the permanent changes of gene expression controlling ALL developmental outcomes. In this article, we will focus on histone acetylation associated with ALL, their implications as biomarkers for prognostic, and their preclinical and clinical applications.
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spelling pubmed-46347192015-11-06 Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia Zhang, Cheng Zhong, Jiang F. Stucky, Andres Chen, Xue-Lian Press, Michael F. Zhang, Xi Clin Epigenetics Review Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease (disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, significant advances have been made in the elucidation of the ALL-associated processes. Thus, we understand that histone acetylation is involved in the permanent changes of gene expression controlling ALL developmental outcomes. In this article, we will focus on histone acetylation associated with ALL, their implications as biomarkers for prognostic, and their preclinical and clinical applications. BioMed Central 2015-11-04 /pmc/articles/PMC4634719/ /pubmed/26543507 http://dx.doi.org/10.1186/s13148-015-0151-8 Text en © Zhang et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhang, Cheng
Zhong, Jiang F.
Stucky, Andres
Chen, Xue-Lian
Press, Michael F.
Zhang, Xi
Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
title Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
title_full Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
title_fullStr Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
title_full_unstemmed Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
title_short Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
title_sort histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634719/
https://www.ncbi.nlm.nih.gov/pubmed/26543507
http://dx.doi.org/10.1186/s13148-015-0151-8
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