Translational research in kidney transplantation and the role of patient engagement

BACKGROUND: Translational research is an evolving discipline that is intended to bridge the gaps between basic science research, clinical research, and implementation in clinical practice. It is a fluid, multidirectional process that requires strong interdisciplinary collaboration to produce research that is relevant to end-users. PURPOSE OF THIS REVIEW: This review summarizes current perspectives on translational research and outlines its relevance and importance to kidney transplantation research. SOURCES OF INFORMATION: Sources of information used for this review include published reports, articles, and research funding websites. FINDINGS: Tissue typing is used as an in-depth example of how translational research has been applied in the field of kidney transplant medicine, and how it has resulted in successful implementation of diagnostic and management options for sensitized individuals undergoing kidney transplantation. The value of actively involving kidney transplant stakeholders (patients, caregivers, and clinicians) in setting research priorities and determining relevant outcomes for future investigation is also discussed. LIMITATIONS: This is a narrative review of the literature which has been partly influenced by the perspectives and experiences of its authors. IMPLICATIONS: Translational and patient-oriented research practices should be incorporated into future research endeavours in the field of kidney transplantation in order to create beneficial change in clinical practice and improve patient outcomes. WHAT WAS KNOWN BEFORE: Translational research which engages patients in the investigative process can enhance the likelihood that medical discoveries will have a meaningful impact at the bedside. WHAT THIS ADDS: This article applies current perspectives on translational research and patient engagement to the field of kidney transplantation, illustrating how these approaches have led to significant advancements in the field. It provides further justification for deliberate, targeted efforts to cross-collaborate and incorporate the patient voice into kidney transplant research.