Cargando…

A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010

BACKGROUND: Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children. METHODS: Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the recor...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Shin Hye, Huh, Kyoung, Won, Sungho, Lee, Kuk-Wha, Park, Mi-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634943/
https://www.ncbi.nlm.nih.gov/pubmed/26539988
http://dx.doi.org/10.1371/journal.pone.0141844
_version_ 1782399443532775424
author Kim, Shin Hye
Huh, Kyoung
Won, Sungho
Lee, Kuk-Wha
Park, Mi-Jung
author_facet Kim, Shin Hye
Huh, Kyoung
Won, Sungho
Lee, Kuk-Wha
Park, Mi-Jung
author_sort Kim, Shin Hye
collection PubMed
description BACKGROUND: Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children. METHODS: Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the records of 21,351 children, including those registered with a diagnosis of CPP for the first time and those diagnosed with CPP who were treated with gonadotropin-releasing hormone analogs. RESULTS: The prevalence of CPP was 55.9 per 100,000 girls and 1.7 per 100,000 boys, respectively. The overall incidence of CPP was 15.3 per 100,000 girls, and 0.6 per 100,000 boys. The annual incidence of CPP in girls significantly increased from 3.3 to 50.4 per 100,000 girls; whereas in boys, it gradually increased from 0.3 to 1.2 per 100,000 boys. The annual incidence of CPP in girls consistently increased at all ages year by year, with greater increases at older ages (≥6 years of age), and smaller increases in girls aged < 6 years. In contrast, the annual incidence remained relatively constant in boys aged < 8 years, while a small increase was observed only in boys aged 8 years. The increase of annual incidence showed significant differences depending on age and gender (P <0.0001). CONCLUSIONS: The annual incidence of CPP has substantially increased among Korean girls over the past 7 years. Continued monitoring of CPP trends among Korean children will be informative.
format Online
Article
Text
id pubmed-4634943
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-46349432015-11-13 A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010 Kim, Shin Hye Huh, Kyoung Won, Sungho Lee, Kuk-Wha Park, Mi-Jung PLoS One Research Article BACKGROUND: Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children. METHODS: Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the records of 21,351 children, including those registered with a diagnosis of CPP for the first time and those diagnosed with CPP who were treated with gonadotropin-releasing hormone analogs. RESULTS: The prevalence of CPP was 55.9 per 100,000 girls and 1.7 per 100,000 boys, respectively. The overall incidence of CPP was 15.3 per 100,000 girls, and 0.6 per 100,000 boys. The annual incidence of CPP in girls significantly increased from 3.3 to 50.4 per 100,000 girls; whereas in boys, it gradually increased from 0.3 to 1.2 per 100,000 boys. The annual incidence of CPP in girls consistently increased at all ages year by year, with greater increases at older ages (≥6 years of age), and smaller increases in girls aged < 6 years. In contrast, the annual incidence remained relatively constant in boys aged < 8 years, while a small increase was observed only in boys aged 8 years. The increase of annual incidence showed significant differences depending on age and gender (P <0.0001). CONCLUSIONS: The annual incidence of CPP has substantially increased among Korean girls over the past 7 years. Continued monitoring of CPP trends among Korean children will be informative. Public Library of Science 2015-11-05 /pmc/articles/PMC4634943/ /pubmed/26539988 http://dx.doi.org/10.1371/journal.pone.0141844 Text en © 2015 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kim, Shin Hye
Huh, Kyoung
Won, Sungho
Lee, Kuk-Wha
Park, Mi-Jung
A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010
title A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010
title_full A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010
title_fullStr A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010
title_full_unstemmed A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010
title_short A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010
title_sort significant increase in the incidence of central precocious puberty among korean girls from 2004 to 2010
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634943/
https://www.ncbi.nlm.nih.gov/pubmed/26539988
http://dx.doi.org/10.1371/journal.pone.0141844
work_keys_str_mv AT kimshinhye asignificantincreaseintheincidenceofcentralprecociouspubertyamongkoreangirlsfrom2004to2010
AT huhkyoung asignificantincreaseintheincidenceofcentralprecociouspubertyamongkoreangirlsfrom2004to2010
AT wonsungho asignificantincreaseintheincidenceofcentralprecociouspubertyamongkoreangirlsfrom2004to2010
AT leekukwha asignificantincreaseintheincidenceofcentralprecociouspubertyamongkoreangirlsfrom2004to2010
AT parkmijung asignificantincreaseintheincidenceofcentralprecociouspubertyamongkoreangirlsfrom2004to2010
AT kimshinhye significantincreaseintheincidenceofcentralprecociouspubertyamongkoreangirlsfrom2004to2010
AT huhkyoung significantincreaseintheincidenceofcentralprecociouspubertyamongkoreangirlsfrom2004to2010
AT wonsungho significantincreaseintheincidenceofcentralprecociouspubertyamongkoreangirlsfrom2004to2010
AT leekukwha significantincreaseintheincidenceofcentralprecociouspubertyamongkoreangirlsfrom2004to2010
AT parkmijung significantincreaseintheincidenceofcentralprecociouspubertyamongkoreangirlsfrom2004to2010