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A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010
BACKGROUND: Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children. METHODS: Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the recor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634943/ https://www.ncbi.nlm.nih.gov/pubmed/26539988 http://dx.doi.org/10.1371/journal.pone.0141844 |
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author | Kim, Shin Hye Huh, Kyoung Won, Sungho Lee, Kuk-Wha Park, Mi-Jung |
author_facet | Kim, Shin Hye Huh, Kyoung Won, Sungho Lee, Kuk-Wha Park, Mi-Jung |
author_sort | Kim, Shin Hye |
collection | PubMed |
description | BACKGROUND: Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children. METHODS: Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the records of 21,351 children, including those registered with a diagnosis of CPP for the first time and those diagnosed with CPP who were treated with gonadotropin-releasing hormone analogs. RESULTS: The prevalence of CPP was 55.9 per 100,000 girls and 1.7 per 100,000 boys, respectively. The overall incidence of CPP was 15.3 per 100,000 girls, and 0.6 per 100,000 boys. The annual incidence of CPP in girls significantly increased from 3.3 to 50.4 per 100,000 girls; whereas in boys, it gradually increased from 0.3 to 1.2 per 100,000 boys. The annual incidence of CPP in girls consistently increased at all ages year by year, with greater increases at older ages (≥6 years of age), and smaller increases in girls aged < 6 years. In contrast, the annual incidence remained relatively constant in boys aged < 8 years, while a small increase was observed only in boys aged 8 years. The increase of annual incidence showed significant differences depending on age and gender (P <0.0001). CONCLUSIONS: The annual incidence of CPP has substantially increased among Korean girls over the past 7 years. Continued monitoring of CPP trends among Korean children will be informative. |
format | Online Article Text |
id | pubmed-4634943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46349432015-11-13 A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010 Kim, Shin Hye Huh, Kyoung Won, Sungho Lee, Kuk-Wha Park, Mi-Jung PLoS One Research Article BACKGROUND: Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children. METHODS: Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the records of 21,351 children, including those registered with a diagnosis of CPP for the first time and those diagnosed with CPP who were treated with gonadotropin-releasing hormone analogs. RESULTS: The prevalence of CPP was 55.9 per 100,000 girls and 1.7 per 100,000 boys, respectively. The overall incidence of CPP was 15.3 per 100,000 girls, and 0.6 per 100,000 boys. The annual incidence of CPP in girls significantly increased from 3.3 to 50.4 per 100,000 girls; whereas in boys, it gradually increased from 0.3 to 1.2 per 100,000 boys. The annual incidence of CPP in girls consistently increased at all ages year by year, with greater increases at older ages (≥6 years of age), and smaller increases in girls aged < 6 years. In contrast, the annual incidence remained relatively constant in boys aged < 8 years, while a small increase was observed only in boys aged 8 years. The increase of annual incidence showed significant differences depending on age and gender (P <0.0001). CONCLUSIONS: The annual incidence of CPP has substantially increased among Korean girls over the past 7 years. Continued monitoring of CPP trends among Korean children will be informative. Public Library of Science 2015-11-05 /pmc/articles/PMC4634943/ /pubmed/26539988 http://dx.doi.org/10.1371/journal.pone.0141844 Text en © 2015 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kim, Shin Hye Huh, Kyoung Won, Sungho Lee, Kuk-Wha Park, Mi-Jung A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010 |
title | A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010 |
title_full | A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010 |
title_fullStr | A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010 |
title_full_unstemmed | A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010 |
title_short | A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010 |
title_sort | significant increase in the incidence of central precocious puberty among korean girls from 2004 to 2010 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634943/ https://www.ncbi.nlm.nih.gov/pubmed/26539988 http://dx.doi.org/10.1371/journal.pone.0141844 |
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