Cargando…

Patterns of Circulating Fibroblast Growth Factor 21 in Subjects with and without Type 2 Diabetes

BACKGROUND: Fibroblast growth factor 21 (FGF21) exerts wide-range effects on carbohydrate and lipid metabolism. However, its perturbation in type 2 diabetes mellitus (T2DM) remains elusive. Besides, previous human studies in T2DM simply investigated fasting or stimulated levels of FGF21. The current...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Jingyi, Yu, Haoyong, Mo, Yifei, Ma, Xiaojing, Hao, Yaping, Lu, Wei, Li, Huating, Bao, Yuqian, Zhou, Jian, Jia, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634968/
https://www.ncbi.nlm.nih.gov/pubmed/26540514
http://dx.doi.org/10.1371/journal.pone.0142207
_version_ 1782399449418432512
author Lu, Jingyi
Yu, Haoyong
Mo, Yifei
Ma, Xiaojing
Hao, Yaping
Lu, Wei
Li, Huating
Bao, Yuqian
Zhou, Jian
Jia, Weiping
author_facet Lu, Jingyi
Yu, Haoyong
Mo, Yifei
Ma, Xiaojing
Hao, Yaping
Lu, Wei
Li, Huating
Bao, Yuqian
Zhou, Jian
Jia, Weiping
author_sort Lu, Jingyi
collection PubMed
description BACKGROUND: Fibroblast growth factor 21 (FGF21) exerts wide-range effects on carbohydrate and lipid metabolism. However, its perturbation in type 2 diabetes mellitus (T2DM) remains elusive. Besides, previous human studies in T2DM simply investigated fasting or stimulated levels of FGF21. The current study sought to evaluate the temporal changes of circulating FGF21 in subjects with and without T2DM. METHODS: Ten patients with T2DM and 16 normal controls (NC) were recruited. Participants were categorized as obese (BMI≥25 kg/m(2)) or lean (BMI<25 kg/m(2)). Blood samples were drawn every 30 min within 7 hours (8 a.m.-3 p.m.). Serum FGF21, blood glucose, insulin, free fatty acids (FFAs) and adiponectin were measured in all subjects. RESULTS: The peak levels of FGF21 were observed in the fasting state (8 a.m.) both in T2DM and NC groups (267.35 ±158.72 ng/L vs. 178.93±121.37 ng/L, P = 0.096). FGF21 AUC did not differ significantly between the two groups (T2DM: 949.4±471.47 ng/L; NC: 883.13±561.40 ng/L, P = 0.770). Obese subjects had higher FGF21 levels than lean ones in patients either with or without T2DM. The pattern of FFAs closely resembled that of FGF21. Correlation analysis showed that temporal levels of FGF21 were significantly related to FFAs (r = 0.749, P = 0.002),but not blood glucose, insulin or adiponectin (all P> 0.05). CONCLUSIONS: These findings suggest that the pattern of circulating FGF21 does not differ significantly between T2DM and NC,although T2DM patients showed a trend toward higher fasting FGF21 than healthy subjects. The pattern of circulating FFAs is significantly associated with that of FGF21.
format Online
Article
Text
id pubmed-4634968
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-46349682015-11-13 Patterns of Circulating Fibroblast Growth Factor 21 in Subjects with and without Type 2 Diabetes Lu, Jingyi Yu, Haoyong Mo, Yifei Ma, Xiaojing Hao, Yaping Lu, Wei Li, Huating Bao, Yuqian Zhou, Jian Jia, Weiping PLoS One Research Article BACKGROUND: Fibroblast growth factor 21 (FGF21) exerts wide-range effects on carbohydrate and lipid metabolism. However, its perturbation in type 2 diabetes mellitus (T2DM) remains elusive. Besides, previous human studies in T2DM simply investigated fasting or stimulated levels of FGF21. The current study sought to evaluate the temporal changes of circulating FGF21 in subjects with and without T2DM. METHODS: Ten patients with T2DM and 16 normal controls (NC) were recruited. Participants were categorized as obese (BMI≥25 kg/m(2)) or lean (BMI<25 kg/m(2)). Blood samples were drawn every 30 min within 7 hours (8 a.m.-3 p.m.). Serum FGF21, blood glucose, insulin, free fatty acids (FFAs) and adiponectin were measured in all subjects. RESULTS: The peak levels of FGF21 were observed in the fasting state (8 a.m.) both in T2DM and NC groups (267.35 ±158.72 ng/L vs. 178.93±121.37 ng/L, P = 0.096). FGF21 AUC did not differ significantly between the two groups (T2DM: 949.4±471.47 ng/L; NC: 883.13±561.40 ng/L, P = 0.770). Obese subjects had higher FGF21 levels than lean ones in patients either with or without T2DM. The pattern of FFAs closely resembled that of FGF21. Correlation analysis showed that temporal levels of FGF21 were significantly related to FFAs (r = 0.749, P = 0.002),but not blood glucose, insulin or adiponectin (all P> 0.05). CONCLUSIONS: These findings suggest that the pattern of circulating FGF21 does not differ significantly between T2DM and NC,although T2DM patients showed a trend toward higher fasting FGF21 than healthy subjects. The pattern of circulating FFAs is significantly associated with that of FGF21. Public Library of Science 2015-11-05 /pmc/articles/PMC4634968/ /pubmed/26540514 http://dx.doi.org/10.1371/journal.pone.0142207 Text en © 2015 Lu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lu, Jingyi
Yu, Haoyong
Mo, Yifei
Ma, Xiaojing
Hao, Yaping
Lu, Wei
Li, Huating
Bao, Yuqian
Zhou, Jian
Jia, Weiping
Patterns of Circulating Fibroblast Growth Factor 21 in Subjects with and without Type 2 Diabetes
title Patterns of Circulating Fibroblast Growth Factor 21 in Subjects with and without Type 2 Diabetes
title_full Patterns of Circulating Fibroblast Growth Factor 21 in Subjects with and without Type 2 Diabetes
title_fullStr Patterns of Circulating Fibroblast Growth Factor 21 in Subjects with and without Type 2 Diabetes
title_full_unstemmed Patterns of Circulating Fibroblast Growth Factor 21 in Subjects with and without Type 2 Diabetes
title_short Patterns of Circulating Fibroblast Growth Factor 21 in Subjects with and without Type 2 Diabetes
title_sort patterns of circulating fibroblast growth factor 21 in subjects with and without type 2 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634968/
https://www.ncbi.nlm.nih.gov/pubmed/26540514
http://dx.doi.org/10.1371/journal.pone.0142207
work_keys_str_mv AT lujingyi patternsofcirculatingfibroblastgrowthfactor21insubjectswithandwithouttype2diabetes
AT yuhaoyong patternsofcirculatingfibroblastgrowthfactor21insubjectswithandwithouttype2diabetes
AT moyifei patternsofcirculatingfibroblastgrowthfactor21insubjectswithandwithouttype2diabetes
AT maxiaojing patternsofcirculatingfibroblastgrowthfactor21insubjectswithandwithouttype2diabetes
AT haoyaping patternsofcirculatingfibroblastgrowthfactor21insubjectswithandwithouttype2diabetes
AT luwei patternsofcirculatingfibroblastgrowthfactor21insubjectswithandwithouttype2diabetes
AT lihuating patternsofcirculatingfibroblastgrowthfactor21insubjectswithandwithouttype2diabetes
AT baoyuqian patternsofcirculatingfibroblastgrowthfactor21insubjectswithandwithouttype2diabetes
AT zhoujian patternsofcirculatingfibroblastgrowthfactor21insubjectswithandwithouttype2diabetes
AT jiaweiping patternsofcirculatingfibroblastgrowthfactor21insubjectswithandwithouttype2diabetes