Multiple Origins of Mutations in the mdr1 Gene—A Putative Marker of Chloroquine Resistance in P. vivax

BACKGROUND: Chloroquine combined with primaquine has been the recommended antimalarial treatment of Plasmodium vivax malaria infections for six decades but the efficacy of this treatment regimen is threatened by chloroquine resistance (CQR). Single nucleotide polymorphisms (SNPs) in the multidrug re...

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Detalles Bibliográficos
Autores principales: Schousboe, Mette L., Ranjitkar, Samir, Rajakaruna, Rupika S., Amerasinghe, Priyanie H., Morales, Francisco, Pearce, Richard, Ord, Rosalyn, Leslie, Toby, Rowland, Mark, Gadalla, Nahla B., Konradsen, Flemming, Bygbjerg, Ib C., Roper, Cally, Alifrangis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634971/
https://www.ncbi.nlm.nih.gov/pubmed/26539821
http://dx.doi.org/10.1371/journal.pntd.0004196

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