Cargando…

Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling

Mutations in genes encoding cilia proteins cause human ciliopathies, diverse disorders affecting many tissues. Individual genes can be linked to ciliopathies with dramatically different phenotypes, suggesting that genetic modifiers may participate in their pathogenesis. The ciliary transition zone c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yee, Laura E., Garcia-Gonzalo, Francesc R., Bowie, Rachel V., Li, Chunmei, Kennedy, Julie K., Ashrafi, Kaveh, Blacque, Oliver E., Leroux, Michel R., Reiter, Jeremy F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635004/ https://www.ncbi.nlm.nih.gov/pubmed/26540106 http://dx.doi.org/10.1371/journal.pgen.1005627

Ejemplares similares

Scoring a backstage pass: Mechanisms of ciliogenesis and ciliary access
por: Garcia-Gonzalo, Francesc R., et al.
Publicado: (2012)

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis
por: Williams, Corey L., et al.
Publicado: (2011)

A transition zone complex of ciliopathy proteins regulates ciliary composition
por: Reiter, JF, et al.
Publicado: (2012)

A ciliopathy complex builds distal appendages to initiate ciliogenesis
por: Kumar, Dhivya, et al.
Publicado: (2021)

Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics
por: Chen, Nansheng, et al.
Publicado: (2006)

A Transition Zone Complex Regulates Mammalian Ciliogenesis and Ciliary Membrane Composition
por: Garcia-Gonzalo, Francesc R., et al.
Publicado: (2011)

A picture tells a thousand words: transmission electron microscopy of the ciliary transition zone in C. elegans
por: Bowie, R, et al.
Publicado: (2012)

A high-throughput genome-wide siRNA screen for ciliogenesis identifies new ciliary functional components and ciliopathy genes
por: Szymanska, K, et al.
Publicado: (2015)

Identification of C. elegans RAB-5-dependent downstream effectors as regulators of ciliogenesis and ciliary membrane homeostasis
por: Scheidel, N, et al.
Publicado: (2015)

Scrutinizing ciliopathies by unravelling the ciliary interactome
por: van Reeuwijk, J, et al.
Publicado: (2012)

MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone
por: Li, Chunmei, et al.
Publicado: (2016)

Ciliary Dyneins and Dynein Related Ciliopathies
por: Antony, Dinu, et al.
Publicado: (2021)

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes
por: Wheway, Gabrielle, et al.
Publicado: (2015)

Reversal of ciliary mechanisms of disassembly rescues olfactory dysfunction in ciliopathies
por: Xie, Chao, et al.
Publicado: (2022)

Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects
por: Chen, Holly Y, et al.
Publicado: (2023)

Differential requirements of ciliogenic/ciliopathy module components in restricting Joubert syndrome-associated Arl13b to a C. elegans Inv-like ciliary compartment
por: Blacque, O, et al.
Publicado: (2012)

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies
por: Breslow, David K., et al.
Publicado: (2018)

Unique among ciliopathies: primary ciliary dyskinesia, a motile cilia disorder
por: Praveen, Kavita, et al.
Publicado: (2015)

Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation
por: Odabasi, Ezgi, et al.
Publicado: (2019)

The Trp73 Mutant Mice: A Ciliopathy Model That Uncouples Ciliogenesis From Planar Cell Polarity
por: Marques, Margarita M., et al.
Publicado: (2019)

Bioinformatic analysis of ciliary transition zone proteins reveals insights into the evolution of ciliopathy networks
por: Barker, Amy R, et al.
Publicado: (2014)

Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport
por: Jensen, Victor L., et al.
Publicado: (2016)

PACRG, a protein linked to ciliary motility, mediates cellular signaling
por: Loucks, Catrina M., et al.
Publicado: (2016)

Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish
por: Maerz, Lars D., et al.
Publicado: (2019)

Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition
por: Rao, Kollu N., et al.
Publicado: (2015)

Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins
por: Mohieldin, Ashraf M., et al.
Publicado: (2021)

Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis
por: Oh, Yoon Seon, et al.
Publicado: (2019)

Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts
por: Eintracht, Jonathan, et al.
Publicado: (2021)

IK is essentially involved in ciliogenesis as an upstream regulator of oral-facial-digital syndrome ciliopathy gene, ofd1
por: Ka, Hye In, et al.
Publicado: (2023)

Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis
por: Walentek, Peter, et al.
Publicado: (2016)

Host Antiviral Response Suppresses Ciliogenesis and Motile Ciliary Functions in the Nasal Epithelium
por: Chen, Qianmin, et al.
Publicado: (2020)

TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone
por: Roberson, Elle C., et al.
Publicado: (2015)

Role of CSPP-L in recruitment of ciliopathy proteins to centriolar satellites and the ciliary transition zone
por: Patzke, S, et al.
Publicado: (2012)

Interpreting ciliopathy-associated missense variants of uncertain significance (VUS) in Caenorhabditis elegans
por: Lange, Karen I, et al.
Publicado: (2021)

Molecular basis underlying the ciliary defects caused by IFT52 variations found in skeletal ciliopathies
por: Ishida, Yamato, et al.
Publicado: (2022)

The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic
por: Turn, Rachel E., et al.
Publicado: (2022)

Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function
por: Mukherjee, Ishita, et al.
Publicado: (2019)

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD
por: Ancel, Julien, et al.
Publicado: (2021)

Paramecium, a Model to Study Ciliary Beating and Ciliogenesis: Insights From Cutting-Edge Approaches
por: Bouhouche, K., et al.
Publicado: (2022)

Deletion of CEP164 in mouse photoreceptors post-ciliogenesis interrupts ciliary intraflagellar transport (IFT)
por: Reed, Michelle, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t2ueh16hrj6p4u7modtv6n20n5