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The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (⩾60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 progno...

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Autores principales: Díaz-Beyá, M, Brunet, S, Nomdedéu, J, Cordeiro, A, Tormo, M, Escoda, L, Ribera, J M, Arnan, M, Heras, I, Gallardo, D, Bargay, J, Queipo de Llano, M P, Salamero, O, Martí, J M, Sampol, A, Pedro, C, Hoyos, M, Pratcorona, M, Castellano, J J, Nomdedeu, M, Risueño, R M, Sierra, J, Monzó, M, Navarro, A, Esteve, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635188/
https://www.ncbi.nlm.nih.gov/pubmed/26430723
http://dx.doi.org/10.1038/bcj.2015.76
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author Díaz-Beyá, M
Brunet, S
Nomdedéu, J
Cordeiro, A
Tormo, M
Escoda, L
Ribera, J M
Arnan, M
Heras, I
Gallardo, D
Bargay, J
Queipo de Llano, M P
Salamero, O
Martí, J M
Sampol, A
Pedro, C
Hoyos, M
Pratcorona, M
Castellano, J J
Nomdedeu, M
Risueño, R M
Sierra, J
Monzó, M
Navarro, A
Esteve, J
author_facet Díaz-Beyá, M
Brunet, S
Nomdedéu, J
Cordeiro, A
Tormo, M
Escoda, L
Ribera, J M
Arnan, M
Heras, I
Gallardo, D
Bargay, J
Queipo de Llano, M P
Salamero, O
Martí, J M
Sampol, A
Pedro, C
Hoyos, M
Pratcorona, M
Castellano, J J
Nomdedeu, M
Risueño, R M
Sierra, J
Monzó, M
Navarro, A
Esteve, J
author_sort Díaz-Beyá, M
collection PubMed
description Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (⩾60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P=0.0025), shorter leukemia-free survival (P=0.026) and higher cumulative incidence of relapse (P=0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P=0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML.
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spelling pubmed-46351882015-11-25 The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia Díaz-Beyá, M Brunet, S Nomdedéu, J Cordeiro, A Tormo, M Escoda, L Ribera, J M Arnan, M Heras, I Gallardo, D Bargay, J Queipo de Llano, M P Salamero, O Martí, J M Sampol, A Pedro, C Hoyos, M Pratcorona, M Castellano, J J Nomdedeu, M Risueño, R M Sierra, J Monzó, M Navarro, A Esteve, J Blood Cancer J Original Article Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (⩾60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P=0.0025), shorter leukemia-free survival (P=0.026) and higher cumulative incidence of relapse (P=0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P=0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML. Nature Publishing Group 2015-10 2015-10-02 /pmc/articles/PMC4635188/ /pubmed/26430723 http://dx.doi.org/10.1038/bcj.2015.76 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Díaz-Beyá, M
Brunet, S
Nomdedéu, J
Cordeiro, A
Tormo, M
Escoda, L
Ribera, J M
Arnan, M
Heras, I
Gallardo, D
Bargay, J
Queipo de Llano, M P
Salamero, O
Martí, J M
Sampol, A
Pedro, C
Hoyos, M
Pratcorona, M
Castellano, J J
Nomdedeu, M
Risueño, R M
Sierra, J
Monzó, M
Navarro, A
Esteve, J
The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia
title The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia
title_full The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia
title_fullStr The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia
title_full_unstemmed The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia
title_short The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia
title_sort expression level of baalc-associated microrna mir-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635188/
https://www.ncbi.nlm.nih.gov/pubmed/26430723
http://dx.doi.org/10.1038/bcj.2015.76
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