Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody

Geographical expansion and re-emerging new genotypes of the Japanese encephalitis virus (JEV) require the development of novel therapeutic approaches. Here, we studied a non-conventional approach for antibody therapy and show that, upon exposure to heme, a fraction of natural human immunoglobulins a...

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Detalles Bibliográficos
Autores principales: Gupta, Nimesh, de Wispelaere, Mélissanne, Lecerf, Maxime, Kalia, Manjula, Scheel, Tobias, Vrati, Sudhanshu, Berek, Claudia, Kaveri, Srinivas V., Desprès, Philippe, Lacroix-Desmazes, Sébastien, Dimitrov, Jordan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635365/
https://www.ncbi.nlm.nih.gov/pubmed/26542535
http://dx.doi.org/10.1038/srep16248
Descripción
Sumario:Geographical expansion and re-emerging new genotypes of the Japanese encephalitis virus (JEV) require the development of novel therapeutic approaches. Here, we studied a non-conventional approach for antibody therapy and show that, upon exposure to heme, a fraction of natural human immunoglobulins acquires high-affinity reactivity with the antigenic domain-III of JEV E glycoprotein. These JEV-reactive antibodies exhibited neutralizing activity against recently dominant JEV genotypes. This study opens new therapeutic options for Japanese encephalitis.

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