Cargando…

Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450

[Image: see text] Almost all known members of the cytochrome P450 (CYP) superfamily conserve a key cysteine residue that coordinates the heme iron. Although mutation of this residue abolishes monooxygenase activity, recent work has shown that mutation to either serine or histidine unlocks non-natura...

Descripción completa

Detalles Bibliográficos
Autores principales:	McIntosh, John A., Heel, Thomas, Buller, Andrew R., Chio, Linda, Arnold, Frances H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635421/ https://www.ncbi.nlm.nih.gov/pubmed/26299431 http://dx.doi.org/10.1021/jacs.5b07107

Ejemplares similares

Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450
por: Farwell, Christopher C., et al.
Publicado: (2015)

Structural basis of bidirectional allostery across the heme in a cytochrome P450 enzyme
por: Kumar, Amit, et al.
Publicado: (2023)

Heme Exporter FLVCR1a Regulates Heme Synthesis and Degradation and Controls Activity of Cytochromes P450
por: Vinchi, Francesca, et al.
Publicado: (2014)

Control of heme and cytochrome P-450 metabolism by inorganic metals, organometals and synthetic metalloporphyrins.
por: Kappas, A, et al.
Publicado: (1984)

Drug-enhanced carbon monoxide production from heme by cytochrome P450 reductase
por: Vukomanovic, Dragic, et al.
Publicado: (2017)

Conformational Equilibrium of NADPH–Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction
por: Sugishima, Masakazu, et al.
Publicado: (2020)

Strength of Axial Water Ligation in Substrate-Free Cytochrome P450s Is Isoform Dependent
por: Conner, Kip P., et al.
Publicado: (2014)

Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles
por: Richard, Alaina M., et al.
Publicado: (2023)

Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450
por: Otey, Christopher R, et al.
Publicado: (2006)

Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period
Publicado: (1975)

The Cytochrome P450 Homepage
por: Nelson, David R
Publicado: (2009)

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
por: Campelo, Diana, et al.
Publicado: (2018)

Nanosecond heme-to-heme electron transfer rates in a multiheme cytochrome nanowire reported by a spectrally unique His/Met-ligated heme
por: van Wonderen, Jessica H., et al.
Publicado: (2021)

Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase
por: Cheng, Shen, et al.
Publicado: (2021)

Heme Oxygenase Isoforms Differ in Their Subcellular Trafficking during Hypoxia and Are Differentially Modulated by Cytochrome P450 Reductase
por: Linnenbaum, Monika, et al.
Publicado: (2012)

Molecular Lego of Human Cytochrome P450: The Key Role of Heme Domain Flexibility for the Activity of the Chimeric Proteins
por: Catucci, Gianluca, et al.
Publicado: (2022)

Insights into the effect of distal histidine and water hydrogen bonding on NO ligation to ferrous and ferric heme: a DFT study
por: Fateminasab, Fatemeh, et al.
Publicado: (2022)

Cytochrome P450(Blt) Enables Versatile Peptide Cyclisation to Generate Histidine‐ and Tyrosine‐Containing Crosslinked Tripeptide Building Blocks
por: Zhao, Yongwei, et al.
Publicado: (2022)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
por: Rwere, Freeborn, et al.
Publicado: (2021)

Fungal cytochrome P450 database
por: Park, Jongsun, et al.
Publicado: (2008)

Cytochrome P450 humanised mice
por: Gonzalez, Frank J
Publicado: (2004)

Intronic polymorphisms of cytochromes P450
por: Ingelman-Sundberg, Magnus, et al.
Publicado: (2010)

The Role of Cytochromes P450 in Infection
por: Stavropoulou, Elisavet, et al.
Publicado: (2018)

Cytochromes P450, Oxygen, and Evolution
por: Lewis, David F.V., et al.
Publicado: (2001)

Histidine Ligated Iron‐Sulfur Peptides
por: Valer, Luca, et al.
Publicado: (2022)

Fission yeast Dap1 heme iron-coordinating residue Y83 is required for cytochromes P450 function
por: Zhao, Shan, et al.
Publicado: (2022)

Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
por: Zhang, Hai-Feng, et al.
Publicado: (2016)

1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
por: de Montellano, Paul R Ortiz
Publicado: (2018)

Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain
por: Burris-Hiday, Sarah D., et al.
Publicado: (2023)

Membrane anchoring facilitates colocalization of enzymes in plant cytochrome P450 redox systems
por: Laursen, Tomas, et al.
Publicado: (2021)

Structural Insights on the Conversion of Cytochrome P450 to P420
por: Gable, Jessica A., et al.
Publicado: (2022)

Structure and function of the cytochrome P450 peroxygenase enzymes
por: Munro, Andrew W., et al.
Publicado: (2018)

Structural Models for Cytochrome P450—Mediated Catalysis
por: Lewis, David F.V.
Publicado: (2003)

Molecular and Structural Evolution of Cytochrome P450 Aromatase
por: Di Nardo, Giovanna, et al.
Publicado: (2021)

Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate–Histidine Hydrogen Bond
por: Yang, Yuting, et al.
Publicado: (2014)

An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase
por: Mukherjee, Goutam, et al.
Publicado: (2021)

Fungal Cytochrome P450s and the P450 Complement (CYPome) of Fusarium graminearum
por: Shin, Jiyoung, et al.
Publicado: (2018)

Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes
por: Kumar, Santosh, et al.
Publicado: (2012)

Heme oxygenase-1 affects cytochrome P450 function through the formation of heteromeric complexes: Interactions between CYP1A2 and heme oxygenase-1
por: Connick, J. Patrick, et al.
Publicado: (2020)

Identification of danthron as an isoform-specific inhibitor of HEME OXYGENASE-1/cytochrome P450 reductase interaction with anti-tumor activity
por: Chou, Yi-Tai, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_uc9ecp9753bsfjpas55t5e0pbt