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Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia

Therapies to prevent severe neonatal unconjugated hyperbilirubinemia and kernicterus are phototherapy and, in unresponsive cases, exchange transfusion, which has significant morbidity and mortality risks. Neurotoxicity is caused by the fraction of unconjugated bilirubin not bound to albumin (free bi...

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Detalles Bibliográficos
Autores principales: Vodret, Simone, Bortolussi, Giulia, Schreuder, Andrea B., Jašprová, Jana, Vitek, Libor, Verkade, Henkjan J., Muro, Andrés F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635426/
https://www.ncbi.nlm.nih.gov/pubmed/26541892
http://dx.doi.org/10.1038/srep16203