In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia

BACKGROUND: Although progress in children, in adults, ALL still carries a dismal outcome. Here, we explored the in vitro and in vivo activity of PF-00477736 (Pfizer), a potent, selective ATP-competitive small-molecule inhibitor of checkpoint kinase 1 (Chk1) and with lower efficacy of checkpoint kina...

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Detalles Bibliográficos
Autores principales: Iacobucci, Ilaria, Di Rorà, Andrea Ghelli Luserna, Falzacappa, Maria Vittoria Verga, Agostinelli, Claudio, Derenzini, Enrico, Ferrari, Anna, Papayannidis, Cristina, Lonetti, Annalisa, Righi, Simona, Imbrogno, Enrica, Pomella, Silvia, Venturi, Claudia, Guadagnuolo, Viviana, Cattina, Federica, Ottaviani, Emanuela, Abbenante, Maria Chiara, Vitale, Antonella, Elia, Loredana, Russo, Domenico, Zinzani, Pier Luigi, Pileri, Stefano, Pelicci, Pier Giuseppe, Martinelli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635624/
https://www.ncbi.nlm.nih.gov/pubmed/26542114
http://dx.doi.org/10.1186/s13045-015-0206-5

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