Cargando…

H7N9 T-cell epitopes that mimic human sequences are less immunogenic and may induce Treg-mediated tolerance

Avian-origin H7N9 influenza is a novel influenza A virus (IAV) that emerged in humans in China in 2013. Using immunoinformatics tools, we identified several H7N9 T cell epitopes with T cell receptor (TCR)-facing residues identical to those of multiple epitopes from human proteins. We hypothesized th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Rui, Moise, Leonard, Tassone, Ryan, Gutierrez, Andres H, Terry, Frances E, Sangare, Kotou, Ardito, Matthew T, Martin, William D, De Groot, Anne S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635734/ https://www.ncbi.nlm.nih.gov/pubmed/26090577 http://dx.doi.org/10.1080/21645515.2015.1052197

Ejemplares similares

A Method for Individualizing the Prediction of Immunogenicity of Protein Vaccines and Biologic Therapeutics: Individualized T Cell Epitope Measure (iTEM)
por: Cohen, Tobias, et al.
Publicado: (2010)

Immunogenic Consensus Sequence T helper Epitopes for a Pan-Burkholderia Biodefense Vaccine
por: De Groot, Anne S., et al.
Publicado: (2011)

T cell epitope: Friend or Foe? Immunogenicity of biologics in context()
por: Weber, Constanze A., et al.
Publicado: (2009)

iVAX: An integrated toolkit for the selection and optimization of antigens and the design of epitope-driven vaccines
por: Moise, Leonard, et al.
Publicado: (2015)

Conservation of HIV-1 T cell epitopes across time and clades: validation of immunogenic HLA-A2 epitopes selected for the GAIA HIV vaccine
por: De Groot, AS, et al.
Publicado: (2012)

Low immunogenicity predicted for emerging avian-origin H7N9: Implication for influenza vaccine design
por: De Groot, Anne S., et al.
Publicado: (2013)

Further confirmation of broadly conserved, highly immunogenic cross-clade HIV CTL epitopes for inclusion in the GAIA HIV vaccine
por: De Groot, AS, et al.
Publicado: (2012)

Development and validation of an epitope prediction tool for swine (PigMatrix) based on the pocket profile method
por: Gutiérrez, Andres H., et al.
Publicado: (2015)

CHOPPI: A Web Tool for the Analysis of Immunogenicity Risk from Host Cell Proteins in CHO-Based Protein Production
por: Bailey-Kellogg, Chris, et al.
Publicado: (2014)

Immune Tolerance-Adjusted Personalized Immunogenicity Prediction for Pompe Disease
por: De Groot, Anne S., et al.
Publicado: (2021)

In Vivo Validation of Predicted and Conserved T Cell Epitopes in a Swine Influenza Model
por: Gutiérrez, Andres H., et al.
Publicado: (2016)

New Immunoinformatics Tools for Swine: Designing Epitope-Driven Vaccines, Predicting Vaccine Efficacy, and Making Vaccines on Demand
por: Moise, Lenny, et al.
Publicado: (2020)

In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity
por: Cousens, Leslie P., et al.
Publicado: (2012)

T‐cell epitope content comparison (EpiCC) of swine H1 influenza A virus hemagglutinin
por: Gutiérrez, Andres H., et al.
Publicado: (2017)

A comparison of two methods for T cell epitope mapping: “cell free” in vitro versus immunoinformatics
por: Messitt, Timothy J., et al.
Publicado: (2011)

Immune escape and immune camouflage may reduce the efficacy of RTS,S vaccine in Malawi
por: Khan, Sundos, et al.
Publicado: (2019)

An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice
por: Bounds, Callie E., et al.
Publicado: (2017)

Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes
por: Cousens, Leslie P., et al.
Publicado: (2013)

Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics
por: De Groot, Anne S, et al.
Publicado: (2013)

Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools
por: De Groot, Anne S., et al.
Publicado: (2020)

Cross-conservation of T-cell epitopes: Now even more relevant to (H7N9) influenza vaccine design
por: De Groot, Anne S, et al.
Publicado: (2014)

Highly conserved, non-human-like, and cross-reactive SARS-CoV-2 T cell epitopes for COVID-19 vaccine design and validation
por: Meyers, Lauren M., et al.
Publicado: (2021)

Smarter vaccine design will circumvent regulatory T cell-mediated evasion in chronic HIV and HCV infection
por: Moise, Leonard, et al.
Publicado: (2014)

The two-faced T cell epitope: Examining the host-microbe interface with JanusMatrix
por: Moise, Leonard, et al.
Publicado: (2013)

Quantifying the Persistence of Vaccine-Related T Cell Epitopes in Circulating Swine Influenza A Strains from 2013–2017
por: Tan, Swan, et al.
Publicado: (2021)

Dendritic Cell-Mediated, DNA-Based Vaccination against Hepatitis C Induces the Multi-Epitope-Specific Response of Humanized, HLA Transgenic Mice
por: Mishra, Sasmita, et al.
Publicado: (2014)

Human Immune Responses to H. pylori HLA Class II Epitopes Identified by Immunoinformatic Methods
por: Zhang, Songhua, et al.
Publicado: (2014)

Epitope-Based Immunome-Derived Vaccines: A Strategy for Improved Design and Safety
por: De Groot, Anne S., et al.
Publicado: (2008)

Partial pathogen protection by tick-bite sensitization and epitope recognition in peptide-immunized HLA DR3 transgenic mice
por: Shattuck, Wendy M C, et al.
Publicado: (2014)

Identification, Selection and Immune Assessment of Liver Stage CD8 T Cell Epitopes From Plasmodium falciparum
por: Tucker, Kenneth D., et al.
Publicado: (2021)

Treg: tolerance vs immunity
por: Biswas, Moanaro, et al.
Publicado: (2015)

Spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice
por: Liu, Shufeng, et al.
Publicado: (2022)

Identification of immunodominant T cell epitopes induced by natural Zika virus infection
por: Eickhoff, Christopher S., et al.
Publicado: (2023)

Of [hamsters] and men: A new perspective on host cell proteins
por: Gutiérrez, Andres H., et al.
Publicado: (2012)

Artificial Anti-HIV-1 Immunogen Comprising Epitopes of Broadly Neutralizing Antibodies 2F5, 10E8, and a Peptide Mimic of VRC01 Discontinuous Epitope
por: Rudometov, Andrey P., et al.
Publicado: (2019)

Identification and Immune Assessment of T Cell Epitopes in Five Plasmodium falciparum Blood Stage Antigens to Facilitate Vaccine Candidate Selection and Optimization
por: Kotraiah, Vinayaka, et al.
Publicado: (2021)

Investigation of pre-existing reactivity to biotherapeutics can uncover potential immunogenic epitopes and predict immunogenicity risk
por: Bivi, Nicoletta, et al.
Publicado: (2019)

Diversity and evolution of computationally predicted T cell epitopes against human respiratory syncytial virus
por: Chen, Jiani, et al.
Publicado: (2023)

Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes
por: Nakamura, Jun, et al.
Publicado: (2017)

Treg Therapies Revisited: Tolerance Beyond Deletion
por: Pilat, Nina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kiuim2lvj65rn61bjmttvpto3q