Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development

Primary tumor-associated hypoxia stimulates the production of secreted factors that mobilize bone marrow-derived cells, including immunomodulatory myeloid-derived suppressor cells (MDSCs) to pre-metastatic niches. We recently found that the hypoxia-induced enzyme carbonic anhydrase IX (CAIX) promote...

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Detalles Bibliográficos
Autores principales: Chafe, Shawn C, Dedhar, Shoukat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635843/
https://www.ncbi.nlm.nih.gov/pubmed/26587316
http://dx.doi.org/10.1080/2162402X.2015.1048955
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author Chafe, Shawn C
Dedhar, Shoukat
author_facet Chafe, Shawn C
Dedhar, Shoukat
author_sort Chafe, Shawn C
collection PubMed
description Primary tumor-associated hypoxia stimulates the production of secreted factors that mobilize bone marrow-derived cells, including immunomodulatory myeloid-derived suppressor cells (MDSCs) to pre-metastatic niches. We recently found that the hypoxia-induced enzyme carbonic anhydrase IX (CAIX) promotes metastasis by stimulating the G-CSF dependent mobilization of granulocytic MDSCs to the lung pre-metastatic niche.
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spelling pubmed-46358432016-02-03 Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development Chafe, Shawn C Dedhar, Shoukat Oncoimmunology Author's View Primary tumor-associated hypoxia stimulates the production of secreted factors that mobilize bone marrow-derived cells, including immunomodulatory myeloid-derived suppressor cells (MDSCs) to pre-metastatic niches. We recently found that the hypoxia-induced enzyme carbonic anhydrase IX (CAIX) promotes metastasis by stimulating the G-CSF dependent mobilization of granulocytic MDSCs to the lung pre-metastatic niche. Taylor & Francis 2015-06-26 /pmc/articles/PMC4635843/ /pubmed/26587316 http://dx.doi.org/10.1080/2162402X.2015.1048955 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Chafe, Shawn C
Dedhar, Shoukat
Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development
title Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development
title_full Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development
title_fullStr Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development
title_full_unstemmed Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development
title_short Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development
title_sort carving out its niche: a role for carbonic anhydrase ix in pre-metastatic niche development
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635843/
https://www.ncbi.nlm.nih.gov/pubmed/26587316
http://dx.doi.org/10.1080/2162402X.2015.1048955
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