The macrophage: Switches from a passenger to a driver during anticancer therapy

We have recently discovered that BRAF inhibitors induce potent macrophage responses that confer melanoma resistance to therapy. Our studies lay a foundation for the hypothesis that macrophages switch their role from a passenger to a driver for tumor survival during therapeutic treatment, suggesting...

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Detalles Bibliográficos
Autores principales: Wang, Tao, Feldman, Gerald M, Herlyn, Meenhard, Kaufman, Russel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635944/
https://www.ncbi.nlm.nih.gov/pubmed/26587324
http://dx.doi.org/10.1080/2162402X.2015.1052929
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author Wang, Tao
Feldman, Gerald M
Herlyn, Meenhard
Kaufman, Russel E
author_facet Wang, Tao
Feldman, Gerald M
Herlyn, Meenhard
Kaufman, Russel E
author_sort Wang, Tao
collection PubMed
description We have recently discovered that BRAF inhibitors induce potent macrophage responses that confer melanoma resistance to therapy. Our studies lay a foundation for the hypothesis that macrophages switch their role from a passenger to a driver for tumor survival during therapeutic treatment, suggesting that agents that target macrophages can be an important component of “cocktail” anticancer therapy.
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spelling pubmed-46359442016-02-03 The macrophage: Switches from a passenger to a driver during anticancer therapy Wang, Tao Feldman, Gerald M Herlyn, Meenhard Kaufman, Russel E Oncoimmunology Author's View We have recently discovered that BRAF inhibitors induce potent macrophage responses that confer melanoma resistance to therapy. Our studies lay a foundation for the hypothesis that macrophages switch their role from a passenger to a driver for tumor survival during therapeutic treatment, suggesting that agents that target macrophages can be an important component of “cocktail” anticancer therapy. Taylor & Francis 2015-06-01 /pmc/articles/PMC4635944/ /pubmed/26587324 http://dx.doi.org/10.1080/2162402X.2015.1052929 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Wang, Tao
Feldman, Gerald M
Herlyn, Meenhard
Kaufman, Russel E
The macrophage: Switches from a passenger to a driver during anticancer therapy
title The macrophage: Switches from a passenger to a driver during anticancer therapy
title_full The macrophage: Switches from a passenger to a driver during anticancer therapy
title_fullStr The macrophage: Switches from a passenger to a driver during anticancer therapy
title_full_unstemmed The macrophage: Switches from a passenger to a driver during anticancer therapy
title_short The macrophage: Switches from a passenger to a driver during anticancer therapy
title_sort macrophage: switches from a passenger to a driver during anticancer therapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635944/
https://www.ncbi.nlm.nih.gov/pubmed/26587324
http://dx.doi.org/10.1080/2162402X.2015.1052929
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