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Genetic interactions contribute less than additive effects to quantitative trait variation in yeast
Genetic mapping studies of quantitative traits typically focus on detecting loci that contribute additively to trait variation. Genetic interactions are often proposed as a contributing factor to trait variation, but the relative contribution of interactions to trait variation is a subject of debate...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635962/ https://www.ncbi.nlm.nih.gov/pubmed/26537231 http://dx.doi.org/10.1038/ncomms9712 |
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author | Bloom, Joshua S. Kotenko, Iulia Sadhu, Meru J. Treusch, Sebastian Albert, Frank W. Kruglyak, Leonid |
author_facet | Bloom, Joshua S. Kotenko, Iulia Sadhu, Meru J. Treusch, Sebastian Albert, Frank W. Kruglyak, Leonid |
author_sort | Bloom, Joshua S. |
collection | PubMed |
description | Genetic mapping studies of quantitative traits typically focus on detecting loci that contribute additively to trait variation. Genetic interactions are often proposed as a contributing factor to trait variation, but the relative contribution of interactions to trait variation is a subject of debate. Here we use a very large cross between two yeast strains to accurately estimate the fraction of phenotypic variance due to pairwise QTL–QTL interactions for 20 quantitative traits. We find that this fraction is 9% on average, substantially less than the contribution of additive QTL (43%). Statistically significant QTL–QTL pairs typically have small individual effect sizes, but collectively explain 40% of the pairwise interaction variance. We show that pairwise interaction variance is largely explained by pairs of loci at least one of which has a significant additive effect. These results refine our understanding of the genetic architecture of quantitative traits and help guide future mapping studies. |
format | Online Article Text |
id | pubmed-4635962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46359622015-12-10 Genetic interactions contribute less than additive effects to quantitative trait variation in yeast Bloom, Joshua S. Kotenko, Iulia Sadhu, Meru J. Treusch, Sebastian Albert, Frank W. Kruglyak, Leonid Nat Commun Article Genetic mapping studies of quantitative traits typically focus on detecting loci that contribute additively to trait variation. Genetic interactions are often proposed as a contributing factor to trait variation, but the relative contribution of interactions to trait variation is a subject of debate. Here we use a very large cross between two yeast strains to accurately estimate the fraction of phenotypic variance due to pairwise QTL–QTL interactions for 20 quantitative traits. We find that this fraction is 9% on average, substantially less than the contribution of additive QTL (43%). Statistically significant QTL–QTL pairs typically have small individual effect sizes, but collectively explain 40% of the pairwise interaction variance. We show that pairwise interaction variance is largely explained by pairs of loci at least one of which has a significant additive effect. These results refine our understanding of the genetic architecture of quantitative traits and help guide future mapping studies. Nature Pub. Group 2015-11-05 /pmc/articles/PMC4635962/ /pubmed/26537231 http://dx.doi.org/10.1038/ncomms9712 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Bloom, Joshua S. Kotenko, Iulia Sadhu, Meru J. Treusch, Sebastian Albert, Frank W. Kruglyak, Leonid Genetic interactions contribute less than additive effects to quantitative trait variation in yeast |
title | Genetic interactions contribute less than additive effects to quantitative trait variation in yeast |
title_full | Genetic interactions contribute less than additive effects to quantitative trait variation in yeast |
title_fullStr | Genetic interactions contribute less than additive effects to quantitative trait variation in yeast |
title_full_unstemmed | Genetic interactions contribute less than additive effects to quantitative trait variation in yeast |
title_short | Genetic interactions contribute less than additive effects to quantitative trait variation in yeast |
title_sort | genetic interactions contribute less than additive effects to quantitative trait variation in yeast |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635962/ https://www.ncbi.nlm.nih.gov/pubmed/26537231 http://dx.doi.org/10.1038/ncomms9712 |
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