Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity

BACKGROUND: HIV-1-infected and/or immune-activated microglia and macrophages are pivotal in the pathogenesis of HIV-1-associated neurocognitive disorders (HAND). Glutaminase, a metabolic enzyme that facilitates glutamate generation, is upregulated and may play a pathogenic role in HAND. Our previous...

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Detalles Bibliográficos
Autores principales: Wu, Beiqing, Huang, Yunlong, Braun, Alexander L., Tong, Zenghan, Zhao, Runze, Li, Yuju, Liu, Fang, Zheng, Jialin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635976/
https://www.ncbi.nlm.nih.gov/pubmed/26546362
http://dx.doi.org/10.1186/s13024-015-0058-z

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