Cargando…

EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition

BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD(+) biosynthesis from nicotinamide, is one of the major factors regulating cancer cells metabolism and is considered a promising target for treating cancer. The prototypical NAMPT inhibitor FK866 effectively l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zucal, Chiara, D’Agostino, Vito G., Casini, Antonio, Mantelli, Barbara, Thongon, Natthakan, Soncini, Debora, Caffa, Irene, Cea, Michele, Ballestrero, Alberto, Quattrone, Alessandro, Indraccolo, Stefano, Nencioni, Alessio, Provenzani, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636066/ https://www.ncbi.nlm.nih.gov/pubmed/26542945 http://dx.doi.org/10.1186/s12885-015-1845-1

Ejemplares similares

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA
por: Thongon, Natthakan, et al.
Publicado: (2018)

The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level
por: Thongon, Natthakan, et al.
Publicado: (2016)

Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition
por: Caffa, Irene, et al.
Publicado: (2015)

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function
por: D’Agostino, Vito Giuseppe, et al.
Publicado: (2015)

Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells
por: Carreira, Agata Sofia Assuncao, et al.
Publicado: (2023)

Catastrophic NAD(+) Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE
por: Bruzzone, Santina, et al.
Publicado: (2009)

Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents
por: Conforti, Irene, et al.
Publicado: (2023)

Grb7 Upregulation Is a Molecular Adaptation to HER2 Signaling Inhibition Due to Removal of Akt-Mediated Gene Repression
por: Nencioni, Alessio, et al.
Publicado: (2010)

A Novel High Throughput Biochemical Assay to Evaluate the HuR Protein-RNA Complex Formation
por: D’Agostino, Vito G., et al.
Publicado: (2013)

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38(MAPK), and JNK Kinase Pathways
por: Marchesi, Nicoletta, et al.
Publicado: (2018)

Ultrasensitive detection of cancer biomarkers by nickel-based isolation of polydisperse extracellular vesicles from blood
por: Notarangelo, Michela, et al.
Publicado: (2019)

Nutrients in the Prevention of Alzheimer's Disease
por: Cremonini, Anna Laura, et al.
Publicado: (2019)

Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells
por: Cea, Michele, et al.
Publicado: (2011)

Nicotinamide Phosphoribosyl Transferase (Nampt) Is Required for De Novo Lipogenesis in Tumor Cells
por: Bowlby, Sarah C., et al.
Publicado: (2012)

Identification and Characterization of an RRM-Containing, RNA Binding Protein in Acinetobacter baumannii
por: Ciani, Caterina, et al.
Publicado: (2022)

Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity
por: Lynn, Heather, et al.
Publicado: (2023)

A H(2)S-Nampt Dependent Energetic Circuit Is Critical to Survival and Cytoprotection from Damage in Cancer Cells
por: Sanokawa-Akakura, Reiko, et al.
Publicado: (2014)

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model
por: Sociali, Giovanna, et al.
Publicado: (2015)

Fasting plus tyrosine kinase inhibitors in cancer
por: Caffa, Irene, et al.
Publicado: (2015)

Tristetraprolin/ZFP36 Regulates the Turnover of Autoimmune-Associated HLA-DQ mRNAs
por: Pisapia, Laura, et al.
Publicado: (2019)

Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells
por: Latorre, Elisa, et al.
Publicado: (2012)

Actomyosin Interaction: Mechanical and Energetic Properties in Different Nucleotide Binding States
por: Aprodu, Iuliana, et al.
Publicado: (2008)

Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer
por: Brown, David N., et al.
Publicado: (2016)

Regulation of HuR structure and function by dihydrotanshinone-I
por: Lal, Preet, et al.
Publicado: (2017)

C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation
por: Licata, Nausicaa V, et al.
Publicado: (2021)

Different BCR/Abl protein suppression patterns as a converging trait of chronic myeloid leukemia cell adaptation to energy restriction
por: Bono, Silvia, et al.
Publicado: (2016)

Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects
por: Saddi-Rosa, Pedro, et al.
Publicado: (2013)

Gambogic Acid Inhibits Wnt/β-catenin Signaling and Induces ER Stress-Mediated Apoptosis in Human Cholangiocarcinoma
por: Suksen, Kanoknetr, et al.
Publicado: (2021)

Hyper conserved elements in vertebrate mRNA 3′-UTRs reveal a translational network of RNA-binding proteins controlled by HuR
por: Dassi, Erik, et al.
Publicado: (2013)

Expression and Regulation of Nampt in Human Islets
por: Kover, Karen, et al.
Publicado: (2013)

Regulation of Regenerative Periodontal Healing by NAMPT
por: Nokhbehsaim, Marjan, et al.
Publicado: (2013)

Visfatin/Nampt: An Adipokine with Cardiovascular Impact
por: Romacho, Tania, et al.
Publicado: (2013)

Association of Nicotinamide Phosphoribosyltransferase (NAMPT) Gene Polymorphisms and of Serum NAMPT Levels with Dilated Cardiomyopathy in a Chinese Population
por: Dou, Qingyu, et al.
Publicado: (2015)

Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb
por: Ahmed, Mohamed, et al.
Publicado: (2021)

Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators
por: Tang, Siyuan, et al.
Publicado: (2023)

Control of the eIF4E activity: structural insights and pharmacological implications
por: Romagnoli, Alice, et al.
Publicado: (2021)

Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma
por: Gelli, Elisa, et al.
Publicado: (2023)

Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody
por: Quijada, Hector, et al.
Publicado: (2021)

Sirt6 regulates dendritic cell differentiation, maturation, and function
por: Lasigliè, Denise, et al.
Publicado: (2016)

Targeting mTOR and eIF4E: a feasible scenario in ovarian cancer therapy
por: Romagnoli, Alice, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tpupb6lae86sob64ims807182h