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Combination of cetuximab and PP242 synergistically suppress the progression of wild-type KRAS colorectal carcinoma

Mammalian target of rapamycin (mTOR) has been shown to be overactive in human colorectal cancer, but the first-generation mTOR inhibitor, rapamycin, has failed to show clinical efficacy against colorectal cancer. On the other hand, although the second-generation mTOR inhibitor, PP242, has exerted su...

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Detalles Bibliográficos
Autores principales:	Cheng, Lei, Xia, Zuguang, Bian, Xinyu, Li, Guangchao, Hu, Jing, Cao, Ya, Wang, Qing, Qian, Xiaoping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636092/ https://www.ncbi.nlm.nih.gov/pubmed/26586952 http://dx.doi.org/10.2147/OTT.S82453

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