Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4

Oxymatrine (OMT) is a pharmacologically active primary quinolizidine alkaloid with various beneficial and toxic effects. It is confirmed that, after oral administration, OMT could be transformed to the more toxic metabolite matrine (MT), and this process may be through the reduction reaction, but th...

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Detalles Bibliográficos
Autores principales: Liu, Wenqin, Shi, Jian, Zhu, Lijun, Dong, Lingna, Luo, Feifei, Zhao, Min, Wang, Ying, Hu, Ming, Lu, Linlin, Liu, Zhongqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636097/
https://www.ncbi.nlm.nih.gov/pubmed/26586934
http://dx.doi.org/10.2147/DDDT.S92276

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