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Mechanism of Focal Adhesion Kinase Mechanosensing

Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile forces, propagating from the membrane through...

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Detalles Bibliográficos
Autores principales:	Zhou, Jing, Aponte-Santamaría, Camilo, Sturm, Sebastian, Bullerjahn, Jakob Tómas, Bronowska, Agnieszka, Gräter, Frauke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636223/ https://www.ncbi.nlm.nih.gov/pubmed/26544178 http://dx.doi.org/10.1371/journal.pcbi.1004593

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