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SOST Inhibits Prostate Cancer Invasion

Inhibitors of Wnt signaling have been shown to be involved in prostate cancer (PC) metastasis; however the role of Sclerostin (Sost) has not yet been explored. Here we show that elevated Wnt signaling derived from Sost deficient osteoblasts promotes PC invasion, while rhSOST has an inhibitory effect...

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Detalles Bibliográficos
Autores principales:	Hudson, Bryan D., Hum, Nicholas R., Thomas, Cynthia B., Kohlgruber, Ayano, Sebastian, Aimy, Collette, Nicole M., Coleman, Matthew A., Christiansen, Blaine A., Loots, Gabriela G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636315/ https://www.ncbi.nlm.nih.gov/pubmed/26545120 http://dx.doi.org/10.1371/journal.pone.0142058

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