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Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation

INTRODUCTION: Cyclophosphamide is commonly used as an important component in conditioning prior to hematopoietic stem cell transplantation, a curative treatment for several hematological diseases. Cyclophosphamide is a prodrug activated mainly by cytochrome P450 2B6 (CYP2B6) in the liver. A high deg...

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Detalles Bibliográficos
Autores principales:	El-Serafi, Ibrahim, Afsharian, Parvaneh, Moshfegh, Ali, Hassan, Moustapha, Terelius, Ylva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636385/ https://www.ncbi.nlm.nih.gov/pubmed/26544874 http://dx.doi.org/10.1371/journal.pone.0141979

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