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Plasmid DNA Vaccine Co-Immunisation Modulates Cellular and Humoral Immune Responses Induced by Intranasal Inoculation in Mice

BACKGROUND: An effective HIV vaccine will likely require induction of both mucosal and systemic cellular and humoral immune responses. We investigated whether intramuscular (IM) delivery of electroporated plasmid DNA vaccine and simultaneous protein vaccinations by intranasal (IN) and IM routes coul...

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Detalles Bibliográficos
Autores principales:	King, Deborah F. L., McKay, Paul F., Mann, Jamie F. S., Jones, C. Bryn, Shattock, Robin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636430/ https://www.ncbi.nlm.nih.gov/pubmed/26544970 http://dx.doi.org/10.1371/journal.pone.0141557

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