Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Cancer-associated muscle weakness is poorly understood and there is no effective treatment. Here, we find that seven different mouse models of human osteolytic bone metastases, representing breast, lung and prostate cancers, as well as multiple myeloma exhibited impaired muscle function, implicating...

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Detalles Bibliográficos
Autores principales: Waning, David L., Mohammad, Khalid S., Reiken, Steven, Xie, Wenjun, Andersson, Daniel C., John, Sutha, Chiechi, Antonella, Wright, Laura E., Umanskaya, Alisa, Niewolna, Maria, Trivedi, Trupti, Charkhzarrin, Sahba, Khatiwada, Pooja, Wronska, Anetta, Haynes, Ashley, Benassi, Maria Serena, Witzmann, Frank A., Zhen, Gehua, Wang, Xiao, Cao, Xu, Roodman, G. David, Marks, Andrew R., Guise, Theresa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636436/
https://www.ncbi.nlm.nih.gov/pubmed/26457758
http://dx.doi.org/10.1038/nm.3961

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