Loss of BAP1 function leads to EZH2-dependent transformation

BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However, BAP1 and ASXL1 are mutated in distinct cancer types, consistent with independent roles in regulating epigenetic state and malignant transformation. Here we d...

Descripción completa

Detalles Bibliográficos
Autores principales: LaFave, Lindsay M., Béguelin, Wendy, Koche, Richard, Teater, Matt, Spitzer, Barbara, Chramiec, Alan, Papalexi, Efthymia, Keller, Matthew D., Hricik, Todd, Konstantinoff, Katerina, Micol, Jean-Baptiste, Durham, Benjamin, Knutson, Sarah K., Campbell, John E., Blum, Gil, Shi, Xinxu, Doud, Emma H., Krivtsov, Andrei V., Chung, Young Rock, Khodos, Inna, de Stanchina, Elisa, Ouerfelli, Ouathek, Adusumilli, Prasad S., Thomas, Paul M., Kelleher, Neil L., Luo, Minkui, Keilhack, Heike, Abdel-Wahab, Omar, Melnick, Ari, Armstrong, Scott A., Levine, Ross L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636469/
https://www.ncbi.nlm.nih.gov/pubmed/26437366
http://dx.doi.org/10.1038/nm.3947

Ejemplares similares

Ejemplares similares