HLA supertype variation across populations: new insights into the role of natural selection in the evolution of HLA-A and HLA-B polymorphisms

Supertypes are groups of human leukocyte antigen (HLA) alleles which bind overlapping sets of peptides due to sharing specific residues at the anchor positions—the B and F pockets—of the peptide-binding region (PBR). HLA alleles within the same supertype are expected to be functionally similar, whil...

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Detalles Bibliográficos
Autores principales: dos Santos Francisco, Rodrigo, Buhler, Stéphane, Nunes, José Manuel, Bitarello, Bárbara Domingues, França, Gustavo Starvaggi, Meyer, Diogo, Sanchez-Mazas, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636516/
https://www.ncbi.nlm.nih.gov/pubmed/26459025
http://dx.doi.org/10.1007/s00251-015-0875-9

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