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Synthesis and evaluation of MePEG-PCL diblock copolymers: surface properties and controlled release behavior

The amphiphilic block copolymers are composed of various combinations of hydrophilic and hydrophobic block unimers. The variation in unimer ratio alters the surface as well as micelle-forming properties of the block copolymers. These nanoscopic micelles have the ability to encapsulate hydrophobic co...

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Autores principales: Mohanty, Anjan Kumar, Jana, Utpal, Manna, Prabal Kumar, Mohanta, Guru Prasad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636528/
https://www.ncbi.nlm.nih.gov/pubmed/26566467
http://dx.doi.org/10.1007/s40204-015-0040-4
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author Mohanty, Anjan Kumar
Jana, Utpal
Manna, Prabal Kumar
Mohanta, Guru Prasad
author_facet Mohanty, Anjan Kumar
Jana, Utpal
Manna, Prabal Kumar
Mohanta, Guru Prasad
author_sort Mohanty, Anjan Kumar
collection PubMed
description The amphiphilic block copolymers are composed of various combinations of hydrophilic and hydrophobic block unimers. The variation in unimer ratio alters the surface as well as micelle-forming properties of the block copolymers. These nanoscopic micelles have the ability to encapsulate hydrophobic compounds and act as potential drug carrier. MePEG-PCL copolymers with various block lengths were synthesized by ring-opening polymerization and characterized by (1)HNMR, GPC, WXRD and DSC. The number average molecular weight of the block copolymer was found to vary from 7511 to 21,270 as determined by GPC and (1)HNMR studies. The surface topology of the polymer films was determined by AFM analysis, which shows a smoother surface with increased MePEG contents in the block copolymers. The protein-binding assay indicates a better biocompatibility of the block copolymers in comparison to MePEG or PCL alone. The CMC of the block copolymer provides the information about micelle formations for encapsulation of hydrophobic materials and affects the in vitro release.
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spelling pubmed-46365282015-11-10 Synthesis and evaluation of MePEG-PCL diblock copolymers: surface properties and controlled release behavior Mohanty, Anjan Kumar Jana, Utpal Manna, Prabal Kumar Mohanta, Guru Prasad Prog Biomater Original Research The amphiphilic block copolymers are composed of various combinations of hydrophilic and hydrophobic block unimers. The variation in unimer ratio alters the surface as well as micelle-forming properties of the block copolymers. These nanoscopic micelles have the ability to encapsulate hydrophobic compounds and act as potential drug carrier. MePEG-PCL copolymers with various block lengths were synthesized by ring-opening polymerization and characterized by (1)HNMR, GPC, WXRD and DSC. The number average molecular weight of the block copolymer was found to vary from 7511 to 21,270 as determined by GPC and (1)HNMR studies. The surface topology of the polymer films was determined by AFM analysis, which shows a smoother surface with increased MePEG contents in the block copolymers. The protein-binding assay indicates a better biocompatibility of the block copolymers in comparison to MePEG or PCL alone. The CMC of the block copolymer provides the information about micelle formations for encapsulation of hydrophobic materials and affects the in vitro release. Springer Berlin Heidelberg 2015-08-20 /pmc/articles/PMC4636528/ /pubmed/26566467 http://dx.doi.org/10.1007/s40204-015-0040-4 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Mohanty, Anjan Kumar
Jana, Utpal
Manna, Prabal Kumar
Mohanta, Guru Prasad
Synthesis and evaluation of MePEG-PCL diblock copolymers: surface properties and controlled release behavior
title Synthesis and evaluation of MePEG-PCL diblock copolymers: surface properties and controlled release behavior
title_full Synthesis and evaluation of MePEG-PCL diblock copolymers: surface properties and controlled release behavior
title_fullStr Synthesis and evaluation of MePEG-PCL diblock copolymers: surface properties and controlled release behavior
title_full_unstemmed Synthesis and evaluation of MePEG-PCL diblock copolymers: surface properties and controlled release behavior
title_short Synthesis and evaluation of MePEG-PCL diblock copolymers: surface properties and controlled release behavior
title_sort synthesis and evaluation of mepeg-pcl diblock copolymers: surface properties and controlled release behavior
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636528/
https://www.ncbi.nlm.nih.gov/pubmed/26566467
http://dx.doi.org/10.1007/s40204-015-0040-4
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