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The relationship between epicardial fat tissue thickness and visceral adipose tissue in lean patients with polycystic ovary syndrome

BACKGROUND: Polycystic ovary syndrome (PCOS) is related to metabolic syndrome, insulin resistance, and cardiovascular metabolic syndromes. This is particularly true for individuals with central and abdominal obesity because visceral abdominal adipose tissue (VAAT) and epicardial adipose tissue (EAT)...

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Autores principales: Arpaci, Dilek, Gurkan Tocoglu, Aysel, Yilmaz, Sabiye, Ergenc, Hasan, Tamer, Ali, Keser, Nurgul, Gunduz, Huseyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636769/
https://www.ncbi.nlm.nih.gov/pubmed/26545735
http://dx.doi.org/10.1186/s13048-015-0197-4
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author Arpaci, Dilek
Gurkan Tocoglu, Aysel
Yilmaz, Sabiye
Ergenc, Hasan
Tamer, Ali
Keser, Nurgul
Gunduz, Huseyin
author_facet Arpaci, Dilek
Gurkan Tocoglu, Aysel
Yilmaz, Sabiye
Ergenc, Hasan
Tamer, Ali
Keser, Nurgul
Gunduz, Huseyin
author_sort Arpaci, Dilek
collection PubMed
description BACKGROUND: Polycystic ovary syndrome (PCOS) is related to metabolic syndrome, insulin resistance, and cardiovascular metabolic syndromes. This is particularly true for individuals with central and abdominal obesity because visceral abdominal adipose tissue (VAAT) and epicardial adipose tissue (EAT) produce a large number of proinflammatory and proatherogenic cytokines. The present study aimed to determine whether there are changes in VAAT and EAT levels which were considered as indirect predictors for subclinical atherosclerosis in lean patients with PCOS. METHODS: The clinical and demographic characteristics of 35 patients with PCOS and 38 healthy control subjects were recorded for the present study. Additionally, the serum levels of various biochemical parameters were measured and EAT levels were assessed using 2D-transthoracic echocardiography. RESULTS: There were no significant differences in mean age (p = 0.056) or mean body mass index (BMI) (p = 0.446) between the patient and control groups. However, the body fat percentage, waist-to-hip ratio, amount of abdominal subcutaneous adipose tissue, and VAAT thickness were higher in the PCOS patient group than in the control group. The amounts of EAT in the patient and control groups were similar (p = 0.384). EAT was correlated with BMI, fat mass, waist circumference, and hip circumference but not with any biochemical metabolic parameters including the homeostasis model assessment of insulin resistance index or the levels of triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein (HDL) cholesterol. However, there was a small positive correlation between the amounts of VAAT and EAT. VAAT was directly correlated with body fat parameters such as BMI, fat mass, and abdominal subcutaneous adipose thickness and inversely correlated with the HDL cholesterol level. CONCLUSIONS: The present study found that increased abdominal adipose tissue in patients with PCOS was associated with atherosclerosis. Additionally, EAT may aid in the determination of the risk of atherosclerosis in patients with PCOS because it is easily measured.
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spelling pubmed-46367692015-11-08 The relationship between epicardial fat tissue thickness and visceral adipose tissue in lean patients with polycystic ovary syndrome Arpaci, Dilek Gurkan Tocoglu, Aysel Yilmaz, Sabiye Ergenc, Hasan Tamer, Ali Keser, Nurgul Gunduz, Huseyin J Ovarian Res Research BACKGROUND: Polycystic ovary syndrome (PCOS) is related to metabolic syndrome, insulin resistance, and cardiovascular metabolic syndromes. This is particularly true for individuals with central and abdominal obesity because visceral abdominal adipose tissue (VAAT) and epicardial adipose tissue (EAT) produce a large number of proinflammatory and proatherogenic cytokines. The present study aimed to determine whether there are changes in VAAT and EAT levels which were considered as indirect predictors for subclinical atherosclerosis in lean patients with PCOS. METHODS: The clinical and demographic characteristics of 35 patients with PCOS and 38 healthy control subjects were recorded for the present study. Additionally, the serum levels of various biochemical parameters were measured and EAT levels were assessed using 2D-transthoracic echocardiography. RESULTS: There were no significant differences in mean age (p = 0.056) or mean body mass index (BMI) (p = 0.446) between the patient and control groups. However, the body fat percentage, waist-to-hip ratio, amount of abdominal subcutaneous adipose tissue, and VAAT thickness were higher in the PCOS patient group than in the control group. The amounts of EAT in the patient and control groups were similar (p = 0.384). EAT was correlated with BMI, fat mass, waist circumference, and hip circumference but not with any biochemical metabolic parameters including the homeostasis model assessment of insulin resistance index or the levels of triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein (HDL) cholesterol. However, there was a small positive correlation between the amounts of VAAT and EAT. VAAT was directly correlated with body fat parameters such as BMI, fat mass, and abdominal subcutaneous adipose thickness and inversely correlated with the HDL cholesterol level. CONCLUSIONS: The present study found that increased abdominal adipose tissue in patients with PCOS was associated with atherosclerosis. Additionally, EAT may aid in the determination of the risk of atherosclerosis in patients with PCOS because it is easily measured. BioMed Central 2015-11-06 /pmc/articles/PMC4636769/ /pubmed/26545735 http://dx.doi.org/10.1186/s13048-015-0197-4 Text en © Arpaci et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Arpaci, Dilek
Gurkan Tocoglu, Aysel
Yilmaz, Sabiye
Ergenc, Hasan
Tamer, Ali
Keser, Nurgul
Gunduz, Huseyin
The relationship between epicardial fat tissue thickness and visceral adipose tissue in lean patients with polycystic ovary syndrome
title The relationship between epicardial fat tissue thickness and visceral adipose tissue in lean patients with polycystic ovary syndrome
title_full The relationship between epicardial fat tissue thickness and visceral adipose tissue in lean patients with polycystic ovary syndrome
title_fullStr The relationship between epicardial fat tissue thickness and visceral adipose tissue in lean patients with polycystic ovary syndrome
title_full_unstemmed The relationship between epicardial fat tissue thickness and visceral adipose tissue in lean patients with polycystic ovary syndrome
title_short The relationship between epicardial fat tissue thickness and visceral adipose tissue in lean patients with polycystic ovary syndrome
title_sort relationship between epicardial fat tissue thickness and visceral adipose tissue in lean patients with polycystic ovary syndrome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636769/
https://www.ncbi.nlm.nih.gov/pubmed/26545735
http://dx.doi.org/10.1186/s13048-015-0197-4
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