Cargando…

Improvement of spontaneous locomotor activity with JAK inhibition by JTE-052 in rat adjuvant-induced arthritis

BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint destruction, disability, and decreased quality of life (QOL). Inhibition of Janus kinase (JAK) signaling ameliorates articular inflammation and joint destruction in animal models of RA, but its effects on beh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tanimoto, Atsuo, Shinozaki, Yuichi, Nozawa, Keisuke, Kimoto, Yukari, Amano, Wataru, Matsuo, Akira, Yamaguchi, Takayuki, Matsushita, Mutsuyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636776/ https://www.ncbi.nlm.nih.gov/pubmed/26546348 http://dx.doi.org/10.1186/s12891-015-0802-0

Ejemplares similares

Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo
por: Tanimoto, Atsuo, et al.
Publicado: (2014)

JTE-852, a novel spleen tyrosine kinase inhibitor, blocks antigen-induced allergic reactions in rats
por: KATO, Toshinobu, et al.
Publicado: (2018)

Step-Double-Zone-JTE for SiC Devices with Increased Tolerance to JTE Dose and Surface Charges
por: Huang, Yifei, et al.
Publicado: (2018)

Phase 1 studies to assess the safety, tolerability and pharmacokinetics of JTE‐052 (a novel Janus kinase inhibitor) ointment in Japanese healthy volunteers and patients with atopic dermatitis
por: Nakagawa, Hidemi, et al.
Publicado: (2018)

JTE: first Impact Factor of 2.683
por: Knowles, Jonathan, et al.
Publicado: (2018)

Characterization and Fabrication of the CFM-JTE for 4H-SiC Power Device with High-Efficiency Protection and Increased JTE Dose Tolerance Window
por: Wen, Yi, et al.
Publicado: (2020)

Direct Stimulatory Effects of the CB(2) Ligand JTE 907 in Human and Mouse Islets
por: Ruz-Maldonado, Inmaculada, et al.
Publicado: (2021)

Title unknown, CERN-ALEPH-87-052
por: Knobloch, J
Publicado: (1987)

Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522
por: Tomozawa, S, et al.
Publicado: (1999)

JTE-013 Alleviates Pulmonary Fibrosis by Affecting the RhoA/YAP Pathway and Mitochondrial Fusion/Fission
por: Zhou, Jiaxu, et al.
Publicado: (2023)

JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats
por: Kobayashi, Hirotoshi, et al.
Publicado: (2005)

Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells
por: Terashita, Tomomi, et al.
Publicado: (2016)

Inhibition of Sphingosine-1-Phosphate Receptor 2 by JTE013 Enhanced Alveolar Bone Regeneration by Promoting Angiogenesis
por: Lory, William, et al.
Publicado: (2023)

The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism
por: Pitman, Melissa R., et al.
Publicado: (2022)

Topical Application of S1P(2) Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice
por: Kang, Jisoo, et al.
Publicado: (2020)

Intratumoral immunotherapy with the TLR7/8 agonist 3M-052
por: Smirnov, DV, et al.
Publicado: (2013)

Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
por: Palumbo, Philip J., et al.
Publicado: (2017)

SAT-LB052 Intravenous Bisphosphonate Therapy in Children with Spinal Muscular Atrophy
por: Nasomyont, Nat, et al.
Publicado: (2019)

SUN-052 Low Vitamin D Is Associated with Coronary Atherosclerosis in Women with HIV
por: Cheru, Lediya, et al.
Publicado: (2019)

Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052
por: Cho, Dae-Hyun, et al.
Publicado: (2023)

P052 Is Circadian Adaptation to Night Work Affected by the Intensity of Ambient Lighting?
por: Roach, G, et al.
Publicado: (2023)

Enhanced Persistency of Resting and Active Periods of Locomotor Activity in Schizophrenia
por: Sano, Wataru, et al.
Publicado: (2012)

AB052. The nursing of endoscopic submucosal dissection for non-muscle invasive bladder tumor
por: Zhan, Fengli, et al.
Publicado: (2018)

Thromboinflammatory Biomarkers in COVID-19: Systematic Review and Meta-analysis of 17,052 Patients
por: Chaudhary, Rahul, et al.
Publicado: (2021)

ODP052 Recurrent Pheochromocytoma Concerning For Surgical Seeding From Prior Partial Adrenalectomy
por: Upadhyaya, Neelam, et al.
Publicado: (2022)

P052 Treatment preferences and help seeking behaviours of Australian adults with insomnia symptoms
por: Haycock, J, et al.
Publicado: (2022)

O052 Patient Preference and Acceptability of Sleep Diagnostic Tests during early Pregnancy
por: Clements, F, et al.
Publicado: (2023)

SARS-CoV-2 delta (B.1.617.2) spike protein adjuvanted with Alum-3M-052 enhances antibody production and neutralization ability
por: Huang, Hong, et al.
Publicado: (2023)

Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based SARS-CoV-2 RBD vaccine formulated with 3M-052-Alum adjuvant
por: Phoolcharoen, Waranyoo, et al.
Publicado: (2023)

Inhibition of Sphingosine-1-Phosphate Receptor 2 by JTE013 Promoted Osteogenesis by Increasing Vesicle Trafficking, Wnt/Ca(2+), and BMP/Smad Signaling
por: Lin, Simon, et al.
Publicado: (2021)

SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung
por: Routhu, Nanda Kishore, et al.
Publicado: (2021)

A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates
por: Pino, Maria, et al.
Publicado: (2021)

Erectile Dysfunction in Qatar: Prevalence and Risk Factors in 1,052 Participants—A Pilot Study
por: Al Naimi, Abdulla, et al.
Publicado: (2014)

SAT-052 Comparison of Echocardiographic Parameters between Pre- and Post-Adrenalectomy in Patients with Primary Aldosteronism
por: Hoshino, Yoshitomo, et al.
Publicado: (2019)

SUN-052 Effects of Cross-Sex Hormone Therapy on Lipid Metabolism in Transgender Women and Men
por: Kelley, Carly, et al.
Publicado: (2020)

P052. Feasibility and safety of breast cancer surgery during the SARS-COV-2 pandemic
por: Oweis, Deyana, et al.
Publicado: (2021)

Persistent inequities in access to and continuity of gynecologic oncology care during the COVID-19 pandemic (052)
por: Bruce, Shaina, et al.
Publicado: (2022)

P052 Mental health predictors for shift work disorder in paramedics during their early career
por: Harris, R, et al.
Publicado: (2021)

AB052. The study of laparoscopic radical prostatectomy vs. robot-assisted laparoscopic prostatectomy on sexual function
por: Yuan, Jianlin
Publicado: (2016)

High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants
por: Willeit, Peter, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_uju4ct7h55ds0e87stbq1llq36