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Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide

BACKGROUND: Temozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase (MGMT) in tumor tissue. Here we used MGMT-expressing glioblastoma stem cells (G...

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Detalles Bibliográficos
Autores principales:	Tso, Jonathan L., Yang, Shuai, Menjivar, Jimmy C., Yamada, Kazunari, Zhang, Yibei, Hong, Irene, Bui, Yvonne, Stream, Alexandra, McBride, William H., Liau, Linda M., Nelson, Stanley F., Cloughesy, Timothy F., Yong, William H., Lai, Albert, Tso, Cho-Lea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636799/ https://www.ncbi.nlm.nih.gov/pubmed/26546412 http://dx.doi.org/10.1186/s12943-015-0459-1

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