Cargando…

Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings

Holmes proposed not only the term ataxia, but also opposite clinical signs related to muscle recruitment, which have escaped clinical attention; (1) asthenia, representing delay in initiating muscle contraction and slowness in attaining exertion of full power, and (2) adventitiousness, representing...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishikawa, Takahiro, Kakei, Shinji, Mitoma, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636821/
https://www.ncbi.nlm.nih.gov/pubmed/26550482
http://dx.doi.org/10.1186/s40673-015-0033-z
_version_ 1782399711666241536
author Ishikawa, Takahiro
Kakei, Shinji
Mitoma, Hiroshi
author_facet Ishikawa, Takahiro
Kakei, Shinji
Mitoma, Hiroshi
author_sort Ishikawa, Takahiro
collection PubMed
description Holmes proposed not only the term ataxia, but also opposite clinical signs related to muscle recruitment, which have escaped clinical attention; (1) asthenia, representing delay in initiating muscle contraction and slowness in attaining exertion of full power, and (2) adventitiousness, representing adventitious movements. Recent physiological studies have shown that cerebellar outputs are modified by release or facilitation of Purkinje cell-mediated inhibition on dentate neurons. We believe that asthenia and adventitiousness, which correlate with deficits in the control of disinhibition and inhibition, respectively, deserve more attention in clinical examination.
format Online
Article
Text
id pubmed-4636821
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-46368212015-11-08 Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings Ishikawa, Takahiro Kakei, Shinji Mitoma, Hiroshi Cerebellum Ataxias Letter to the Editor Holmes proposed not only the term ataxia, but also opposite clinical signs related to muscle recruitment, which have escaped clinical attention; (1) asthenia, representing delay in initiating muscle contraction and slowness in attaining exertion of full power, and (2) adventitiousness, representing adventitious movements. Recent physiological studies have shown that cerebellar outputs are modified by release or facilitation of Purkinje cell-mediated inhibition on dentate neurons. We believe that asthenia and adventitiousness, which correlate with deficits in the control of disinhibition and inhibition, respectively, deserve more attention in clinical examination. BioMed Central 2015-11-06 /pmc/articles/PMC4636821/ /pubmed/26550482 http://dx.doi.org/10.1186/s40673-015-0033-z Text en © Ishikawa et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Ishikawa, Takahiro
Kakei, Shinji
Mitoma, Hiroshi
Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings
title Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings
title_full Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings
title_fullStr Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings
title_full_unstemmed Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings
title_short Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings
title_sort overlooked holmes’ clinical signs: reevaluation by recent physiological findings
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636821/
https://www.ncbi.nlm.nih.gov/pubmed/26550482
http://dx.doi.org/10.1186/s40673-015-0033-z
work_keys_str_mv AT ishikawatakahiro overlookedholmesclinicalsignsreevaluationbyrecentphysiologicalfindings
AT kakeishinji overlookedholmesclinicalsignsreevaluationbyrecentphysiologicalfindings
AT mitomahiroshi overlookedholmesclinicalsignsreevaluationbyrecentphysiologicalfindings