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Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings
Holmes proposed not only the term ataxia, but also opposite clinical signs related to muscle recruitment, which have escaped clinical attention; (1) asthenia, representing delay in initiating muscle contraction and slowness in attaining exertion of full power, and (2) adventitiousness, representing...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636821/ https://www.ncbi.nlm.nih.gov/pubmed/26550482 http://dx.doi.org/10.1186/s40673-015-0033-z |
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author | Ishikawa, Takahiro Kakei, Shinji Mitoma, Hiroshi |
author_facet | Ishikawa, Takahiro Kakei, Shinji Mitoma, Hiroshi |
author_sort | Ishikawa, Takahiro |
collection | PubMed |
description | Holmes proposed not only the term ataxia, but also opposite clinical signs related to muscle recruitment, which have escaped clinical attention; (1) asthenia, representing delay in initiating muscle contraction and slowness in attaining exertion of full power, and (2) adventitiousness, representing adventitious movements. Recent physiological studies have shown that cerebellar outputs are modified by release or facilitation of Purkinje cell-mediated inhibition on dentate neurons. We believe that asthenia and adventitiousness, which correlate with deficits in the control of disinhibition and inhibition, respectively, deserve more attention in clinical examination. |
format | Online Article Text |
id | pubmed-4636821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46368212015-11-08 Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings Ishikawa, Takahiro Kakei, Shinji Mitoma, Hiroshi Cerebellum Ataxias Letter to the Editor Holmes proposed not only the term ataxia, but also opposite clinical signs related to muscle recruitment, which have escaped clinical attention; (1) asthenia, representing delay in initiating muscle contraction and slowness in attaining exertion of full power, and (2) adventitiousness, representing adventitious movements. Recent physiological studies have shown that cerebellar outputs are modified by release or facilitation of Purkinje cell-mediated inhibition on dentate neurons. We believe that asthenia and adventitiousness, which correlate with deficits in the control of disinhibition and inhibition, respectively, deserve more attention in clinical examination. BioMed Central 2015-11-06 /pmc/articles/PMC4636821/ /pubmed/26550482 http://dx.doi.org/10.1186/s40673-015-0033-z Text en © Ishikawa et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Letter to the Editor Ishikawa, Takahiro Kakei, Shinji Mitoma, Hiroshi Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings |
title | Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings |
title_full | Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings |
title_fullStr | Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings |
title_full_unstemmed | Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings |
title_short | Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings |
title_sort | overlooked holmes’ clinical signs: reevaluation by recent physiological findings |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636821/ https://www.ncbi.nlm.nih.gov/pubmed/26550482 http://dx.doi.org/10.1186/s40673-015-0033-z |
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