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Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics

BACKGROUND: Non-tuberculous mycobacteria (NTM) infection is an emerging health problem. We present here the Zambia-specific national level data of prevalence, symptomatic, radiological and microbiological characteristics of NTM, using results from a national Tuberculosis (TB) prevalence survey. METH...

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Autores principales: Chanda-Kapata, Pascalina, Kapata, Nathan, Klinkenberg, Eveline, Mulenga, Lutinala, Tembo, Mathias, Katemangwe, Patrick, Sunkutu, Veronica, Mwaba, Peter, Grobusch, Martin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636841/
https://www.ncbi.nlm.nih.gov/pubmed/26545357
http://dx.doi.org/10.1186/s12879-015-1264-6
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author Chanda-Kapata, Pascalina
Kapata, Nathan
Klinkenberg, Eveline
Mulenga, Lutinala
Tembo, Mathias
Katemangwe, Patrick
Sunkutu, Veronica
Mwaba, Peter
Grobusch, Martin P.
author_facet Chanda-Kapata, Pascalina
Kapata, Nathan
Klinkenberg, Eveline
Mulenga, Lutinala
Tembo, Mathias
Katemangwe, Patrick
Sunkutu, Veronica
Mwaba, Peter
Grobusch, Martin P.
author_sort Chanda-Kapata, Pascalina
collection PubMed
description BACKGROUND: Non-tuberculous mycobacteria (NTM) infection is an emerging health problem. We present here the Zambia-specific national level data of prevalence, symptomatic, radiological and microbiological characteristics of NTM, using results from a national Tuberculosis (TB) prevalence survey. METHODS: This was a cross-sectional study of the prevalence of NTM among adults aged 15 years and above, who were participants in a national TB prevalence survey. Participants who had either an abnormal chest x-ray or were symptomatic were considered presumptive TB cases and submitted sputum for smear and culture analysis. HIV testing was performed on an opt-out basis. Symptomatic NTM prevalence was estimated from individual level analysis. RESULTS: Of the 6,123 individuals with presumptive TB, 923 (15.1 %) were found to have NTM, 13 (0.2 %) were MTB/NTM co-infected and 338 (5.5 %) were contaminated (indeterminate). The prevalence of symptomatic NTM was found to be 1,477/100,000 [95 % CI 1010–1943]. Smear positivity, history of cough or chest pain and HIV positivity were risk factors for NTM. CONCLUSION: This first study to estimate the national prevalence of NTM in Zambia indicates that the burden is high. The NTM occurrence in Zambia constitutes both a public health and ethical issue requiring action from health managers.
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spelling pubmed-46368412015-11-08 Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics Chanda-Kapata, Pascalina Kapata, Nathan Klinkenberg, Eveline Mulenga, Lutinala Tembo, Mathias Katemangwe, Patrick Sunkutu, Veronica Mwaba, Peter Grobusch, Martin P. BMC Infect Dis Research Article BACKGROUND: Non-tuberculous mycobacteria (NTM) infection is an emerging health problem. We present here the Zambia-specific national level data of prevalence, symptomatic, radiological and microbiological characteristics of NTM, using results from a national Tuberculosis (TB) prevalence survey. METHODS: This was a cross-sectional study of the prevalence of NTM among adults aged 15 years and above, who were participants in a national TB prevalence survey. Participants who had either an abnormal chest x-ray or were symptomatic were considered presumptive TB cases and submitted sputum for smear and culture analysis. HIV testing was performed on an opt-out basis. Symptomatic NTM prevalence was estimated from individual level analysis. RESULTS: Of the 6,123 individuals with presumptive TB, 923 (15.1 %) were found to have NTM, 13 (0.2 %) were MTB/NTM co-infected and 338 (5.5 %) were contaminated (indeterminate). The prevalence of symptomatic NTM was found to be 1,477/100,000 [95 % CI 1010–1943]. Smear positivity, history of cough or chest pain and HIV positivity were risk factors for NTM. CONCLUSION: This first study to estimate the national prevalence of NTM in Zambia indicates that the burden is high. The NTM occurrence in Zambia constitutes both a public health and ethical issue requiring action from health managers. BioMed Central 2015-11-06 /pmc/articles/PMC4636841/ /pubmed/26545357 http://dx.doi.org/10.1186/s12879-015-1264-6 Text en © Chanda-Kapata et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Chanda-Kapata, Pascalina
Kapata, Nathan
Klinkenberg, Eveline
Mulenga, Lutinala
Tembo, Mathias
Katemangwe, Patrick
Sunkutu, Veronica
Mwaba, Peter
Grobusch, Martin P.
Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics
title Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics
title_full Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics
title_fullStr Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics
title_full_unstemmed Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics
title_short Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics
title_sort non-tuberculous mycobacteria (ntm) in zambia: prevalence, clinical, radiological and microbiological characteristics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636841/
https://www.ncbi.nlm.nih.gov/pubmed/26545357
http://dx.doi.org/10.1186/s12879-015-1264-6
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