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Role of Exosomal Noncoding RNAs in Lung Carcinogenesis
Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cance...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637011/ https://www.ncbi.nlm.nih.gov/pubmed/26583084 http://dx.doi.org/10.1155/2015/125807 |
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author | Sun, Tao Kalionis, Bill Lv, Guoying Xia, Shijin Gao, Wen |
author_facet | Sun, Tao Kalionis, Bill Lv, Guoying Xia, Shijin Gao, Wen |
author_sort | Sun, Tao |
collection | PubMed |
description | Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cancer. Exosomes are small extracellular membrane vesicles of endocytic origin that are released by many cells and are found in most body fluids. Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth and metastasis. MicroRNAs (miRNAs) are a subclass of ncRNAs that are present in exosomes. miRNAs are taken up by neighboring or distant cells and modulate various functions of recipient cells. Here, we review exosome-derived ncRNAs with a focus on miRNAs and their role in lung cancer biology. |
format | Online Article Text |
id | pubmed-4637011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46370112015-11-18 Role of Exosomal Noncoding RNAs in Lung Carcinogenesis Sun, Tao Kalionis, Bill Lv, Guoying Xia, Shijin Gao, Wen Biomed Res Int Review Article Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cancer. Exosomes are small extracellular membrane vesicles of endocytic origin that are released by many cells and are found in most body fluids. Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth and metastasis. MicroRNAs (miRNAs) are a subclass of ncRNAs that are present in exosomes. miRNAs are taken up by neighboring or distant cells and modulate various functions of recipient cells. Here, we review exosome-derived ncRNAs with a focus on miRNAs and their role in lung cancer biology. Hindawi Publishing Corporation 2015 2015-10-25 /pmc/articles/PMC4637011/ /pubmed/26583084 http://dx.doi.org/10.1155/2015/125807 Text en Copyright © 2015 Tao Sun et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sun, Tao Kalionis, Bill Lv, Guoying Xia, Shijin Gao, Wen Role of Exosomal Noncoding RNAs in Lung Carcinogenesis |
title | Role of Exosomal Noncoding RNAs in Lung Carcinogenesis |
title_full | Role of Exosomal Noncoding RNAs in Lung Carcinogenesis |
title_fullStr | Role of Exosomal Noncoding RNAs in Lung Carcinogenesis |
title_full_unstemmed | Role of Exosomal Noncoding RNAs in Lung Carcinogenesis |
title_short | Role of Exosomal Noncoding RNAs in Lung Carcinogenesis |
title_sort | role of exosomal noncoding rnas in lung carcinogenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637011/ https://www.ncbi.nlm.nih.gov/pubmed/26583084 http://dx.doi.org/10.1155/2015/125807 |
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