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Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation

Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of disease and will remain the main cause of mortality for the near future. Oxidative stress plays a major role in the pathophysiology of cardiac disorders. Several studies have highlighted the cardinal role played b...

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Detalles Bibliográficos
Autores principales: Bai, Yang, Wang, Xiaolu, Zhao, Song, Ma, Chunye, Cui, Jiuwei, Zheng, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637098/
https://www.ncbi.nlm.nih.gov/pubmed/26583056
http://dx.doi.org/10.1155/2015/407580
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author Bai, Yang
Wang, Xiaolu
Zhao, Song
Ma, Chunye
Cui, Jiuwei
Zheng, Yang
author_facet Bai, Yang
Wang, Xiaolu
Zhao, Song
Ma, Chunye
Cui, Jiuwei
Zheng, Yang
author_sort Bai, Yang
collection PubMed
description Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of disease and will remain the main cause of mortality for the near future. Oxidative stress plays a major role in the pathophysiology of cardiac disorders. Several studies have highlighted the cardinal role played by the overproduction of reactive oxygen or nitrogen species in the pathogenesis of ischemic myocardial damage and consequent cardiac dysfunction. Isothiocyanates (ITC) are sulfur-containing compounds that are broadly distributed among cruciferous vegetables. Sulforaphane (SFN) is an ITC shown to possess anticancer activities by both in vivo and epidemiological studies. Recent data have indicated that the beneficial effects of SFN in CVD are due to its antioxidant and anti-inflammatory properties. SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes. This review will summarize the evidence from clinical studies and animal experiments relating to the potential mechanisms by which SFN modulates Nrf2 activation and protects against CVD.
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spelling pubmed-46370982015-11-18 Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation Bai, Yang Wang, Xiaolu Zhao, Song Ma, Chunye Cui, Jiuwei Zheng, Yang Oxid Med Cell Longev Review Article Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of disease and will remain the main cause of mortality for the near future. Oxidative stress plays a major role in the pathophysiology of cardiac disorders. Several studies have highlighted the cardinal role played by the overproduction of reactive oxygen or nitrogen species in the pathogenesis of ischemic myocardial damage and consequent cardiac dysfunction. Isothiocyanates (ITC) are sulfur-containing compounds that are broadly distributed among cruciferous vegetables. Sulforaphane (SFN) is an ITC shown to possess anticancer activities by both in vivo and epidemiological studies. Recent data have indicated that the beneficial effects of SFN in CVD are due to its antioxidant and anti-inflammatory properties. SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes. This review will summarize the evidence from clinical studies and animal experiments relating to the potential mechanisms by which SFN modulates Nrf2 activation and protects against CVD. Hindawi Publishing Corporation 2015 2015-10-25 /pmc/articles/PMC4637098/ /pubmed/26583056 http://dx.doi.org/10.1155/2015/407580 Text en Copyright © 2015 Yang Bai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bai, Yang
Wang, Xiaolu
Zhao, Song
Ma, Chunye
Cui, Jiuwei
Zheng, Yang
Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
title Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
title_full Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
title_fullStr Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
title_full_unstemmed Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
title_short Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
title_sort sulforaphane protects against cardiovascular disease via nrf2 activation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637098/
https://www.ncbi.nlm.nih.gov/pubmed/26583056
http://dx.doi.org/10.1155/2015/407580
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