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Viral Interference and Persistence in Mosquito-Borne Flaviviruses
Mosquito-borne flaviviruses are important pathogens for humans, and the detection of two or more flaviviruses cocirculating in the same geographic area has often been reported. However, the epidemiological impact remains to be determined. Mosquito-borne flaviviruses are primarily transmitted through...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637105/ https://www.ncbi.nlm.nih.gov/pubmed/26583158 http://dx.doi.org/10.1155/2015/873404 |
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author | Salas-Benito, Juan Santiago De Nova-Ocampo, Mónica |
author_facet | Salas-Benito, Juan Santiago De Nova-Ocampo, Mónica |
author_sort | Salas-Benito, Juan Santiago |
collection | PubMed |
description | Mosquito-borne flaviviruses are important pathogens for humans, and the detection of two or more flaviviruses cocirculating in the same geographic area has often been reported. However, the epidemiological impact remains to be determined. Mosquito-borne flaviviruses are primarily transmitted through Aedes and Culex mosquitoes; these viruses establish a life-long or persistent infection without apparent pathological effects. This establishment requires a balance between virus replication and the antiviral host response. Viral interference is a phenomenon whereby one virus inhibits the replication of other viruses, and this condition is frequently associated with persistent infections. Viral interference and persistent infection are determined by several factors, such as defective interfering particles, competition for cellular factors required for translation/replication, and the host antiviral response. The interaction between two flaviviruses typically results in viral interference, indicating that these viruses share common features during the replicative cycle in the vector. The potential mechanisms involved in these processes are reviewed here. |
format | Online Article Text |
id | pubmed-4637105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46371052015-11-18 Viral Interference and Persistence in Mosquito-Borne Flaviviruses Salas-Benito, Juan Santiago De Nova-Ocampo, Mónica J Immunol Res Review Article Mosquito-borne flaviviruses are important pathogens for humans, and the detection of two or more flaviviruses cocirculating in the same geographic area has often been reported. However, the epidemiological impact remains to be determined. Mosquito-borne flaviviruses are primarily transmitted through Aedes and Culex mosquitoes; these viruses establish a life-long or persistent infection without apparent pathological effects. This establishment requires a balance between virus replication and the antiviral host response. Viral interference is a phenomenon whereby one virus inhibits the replication of other viruses, and this condition is frequently associated with persistent infections. Viral interference and persistent infection are determined by several factors, such as defective interfering particles, competition for cellular factors required for translation/replication, and the host antiviral response. The interaction between two flaviviruses typically results in viral interference, indicating that these viruses share common features during the replicative cycle in the vector. The potential mechanisms involved in these processes are reviewed here. Hindawi Publishing Corporation 2015 2015-10-25 /pmc/articles/PMC4637105/ /pubmed/26583158 http://dx.doi.org/10.1155/2015/873404 Text en Copyright © 2015 J. S. Salas-Benito and M. De Nova-Ocampo. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Salas-Benito, Juan Santiago De Nova-Ocampo, Mónica Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
title | Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
title_full | Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
title_fullStr | Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
title_full_unstemmed | Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
title_short | Viral Interference and Persistence in Mosquito-Borne Flaviviruses |
title_sort | viral interference and persistence in mosquito-borne flaviviruses |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637105/ https://www.ncbi.nlm.nih.gov/pubmed/26583158 http://dx.doi.org/10.1155/2015/873404 |
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