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Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism
Glutamine (GLN) is commonly known as an important metabolite used for the growth of cancer cells but the effects of its intake in cancer patients are still not clear. However, GLN is the main substrate for DNA and fatty acid synthesis. On the other hand, it reduces the oxidative stress by glutathion...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637129/ https://www.ncbi.nlm.nih.gov/pubmed/26583064 http://dx.doi.org/10.1155/2015/964321 |
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author | Michalak, Krzysztof Piotr Maćkowska-Kędziora, Agnieszka Sobolewski, Bogusław Woźniak, Piotr |
author_facet | Michalak, Krzysztof Piotr Maćkowska-Kędziora, Agnieszka Sobolewski, Bogusław Woźniak, Piotr |
author_sort | Michalak, Krzysztof Piotr |
collection | PubMed |
description | Glutamine (GLN) is commonly known as an important metabolite used for the growth of cancer cells but the effects of its intake in cancer patients are still not clear. However, GLN is the main substrate for DNA and fatty acid synthesis. On the other hand, it reduces the oxidative stress by glutathione synthesis stimulation, stops the process of cancer cachexia, and nourishes the immunological system and the intestine epithelium, as well. The current paper deals with possible positive effects of GLN supplementation and conditions that should be fulfilled to obtain these effects. The analysis of GLN metabolism suggests that the separation of GLN and carbohydrates in the diet can minimize simultaneous supply of ATP (from glucose) and NADPH(2) (from glutamine) to cancer cells. It should support to a larger extent the organism to fight against the cancer rather than the cancer cells. GLN cannot be considered the effective source of ATP for cancers with the impaired oxidative phosphorylation and pyruvate dehydrogenase inhibition. GLN intake restores decreased levels of glutathione in the case of chemotherapy and radiotherapy; thus, it facilitates regeneration processes of the intestine epithelium and immunological system. |
format | Online Article Text |
id | pubmed-4637129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46371292015-11-18 Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism Michalak, Krzysztof Piotr Maćkowska-Kędziora, Agnieszka Sobolewski, Bogusław Woźniak, Piotr Oxid Med Cell Longev Review Article Glutamine (GLN) is commonly known as an important metabolite used for the growth of cancer cells but the effects of its intake in cancer patients are still not clear. However, GLN is the main substrate for DNA and fatty acid synthesis. On the other hand, it reduces the oxidative stress by glutathione synthesis stimulation, stops the process of cancer cachexia, and nourishes the immunological system and the intestine epithelium, as well. The current paper deals with possible positive effects of GLN supplementation and conditions that should be fulfilled to obtain these effects. The analysis of GLN metabolism suggests that the separation of GLN and carbohydrates in the diet can minimize simultaneous supply of ATP (from glucose) and NADPH(2) (from glutamine) to cancer cells. It should support to a larger extent the organism to fight against the cancer rather than the cancer cells. GLN cannot be considered the effective source of ATP for cancers with the impaired oxidative phosphorylation and pyruvate dehydrogenase inhibition. GLN intake restores decreased levels of glutathione in the case of chemotherapy and radiotherapy; thus, it facilitates regeneration processes of the intestine epithelium and immunological system. Hindawi Publishing Corporation 2015 2015-10-25 /pmc/articles/PMC4637129/ /pubmed/26583064 http://dx.doi.org/10.1155/2015/964321 Text en Copyright © 2015 Krzysztof Piotr Michalak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Michalak, Krzysztof Piotr Maćkowska-Kędziora, Agnieszka Sobolewski, Bogusław Woźniak, Piotr Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism |
title | Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism |
title_full | Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism |
title_fullStr | Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism |
title_full_unstemmed | Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism |
title_short | Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism |
title_sort | key roles of glutamine pathways in reprogramming the cancer metabolism |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637129/ https://www.ncbi.nlm.nih.gov/pubmed/26583064 http://dx.doi.org/10.1155/2015/964321 |
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