Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia

BACKGROUND: Tumor-suppressor genes are inactivated by methylation in several cancers including acute myeloid leukemia (AML). Src homology-2 (SH2)-containing protein-tyrosine phosphatase 1 (SHP-1) is a negative regulator of the JAK/STAT pathway. Transcriptional silencing of SHP-1 plays a critical rol...

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Detalles Bibliográficos
Autores principales: Al-Jamal, Hamid Ali Nagi, Mat Jusoh, Siti Asmaa, Hassan, Rosline, Johan, Muhammad Farid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637135/
https://www.ncbi.nlm.nih.gov/pubmed/26547689
http://dx.doi.org/10.1186/s12885-015-1695-x

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