Cargando…

Antagonizing Bcl-2′s BH4 domain in cancer

Detalles Bibliográficos
Autores principales:	Vervloessem, Tamara, Rovere, Rita La, Bultynck, Geert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Editorial
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637201/ https://www.ncbi.nlm.nih.gov/pubmed/26525307

Ejemplares similares

BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models
por: Vervloessem, Tamara, et al.
Publicado: (2020)

BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis
por: Vervliet, Tim, et al.
Publicado: (2018)

Ryanodine receptors are targeted by anti-apoptotic Bcl-X(L) involving its BH4 domain and Lys87 from its BH3 domain
por: Vervliet, Tim, et al.
Publicado: (2015)

Reciprocal sensitivity of diffuse large B-cell lymphoma cells to Bcl-2 inhibitors BIRD-2 versus venetoclax
por: Vervloessem, Tamara, et al.
Publicado: (2017)

DLBCL Cells with Acquired Resistance to Venetoclax Are Not Sensitized to BIRD-2 But Can Be Resensitized to Venetoclax through Bcl-XL Inhibition
por: Kerkhofs, Martijn, et al.
Publicado: (2020)

Allosteric cross-talk between the hydrophobic cleft and the BH4 domain of Bcl-2 in control of inositol 1,4,5-trisphosphate receptor activity
por: Shapovalov, George, et al.
Publicado: (2022)

Recent advances in uncovering the mechanisms contributing to BIRD-2-induced cell death in B-cell cancer cells
por: Kerkhofs, Martijn, et al.
Publicado: (2019)

Selective regulation of IP(3)-receptor-mediated Ca(2+) signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl
por: Monaco, G, et al.
Publicado: (2012)

Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP(3) Receptor
por: Monaco, Giovanni, et al.
Publicado: (2013)

BH4-mimetics and -antagonists: an emerging class of Bcl-2 protein modulators for cancer therapy
por: Nougarède, Adrien, et al.
Publicado: (2018)

IP(3)R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP(3)R-derived peptide targeting the BH4 domain of Bcl-2
por: Akl, H, et al.
Publicado: (2013)

Novel BH4-BCL-2 Domain Antagonists Induce BCL-2-Mediated Apoptosis in Triple-Negative Breast Cancer
por: Kanakaveti, Vishnupriya, et al.
Publicado: (2022)

Mutual Regulation of Bcl-2 Proteins Independent of the BH3 Domain as Shown by the BH3-Lacking Protein Bcl-x(AK)
por: Plötz, Michael, et al.
Publicado: (2012)

Antagonism of Bcl-X(L) is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells
por: Abed, Mohammed Najim, et al.
Publicado: (2016)

Bcl-xL acts as an inhibitor of IP(3)R channels, thereby antagonizing Ca(2+)-driven apoptosis
por: Rosa, Nicolas, et al.
Publicado: (2021)

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2
por: Lavik, Andrew R., et al.
Publicado: (2015)

CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth
por: Lin, Yihua, et al.
Publicado: (2023)

ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca(2+)‐signalling dysregulation or toxicity in pancreatic acinar cells
por: Jakubowska, Monika A, et al.
Publicado: (2018)

Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members
por: Hosseini, Ali, et al.
Publicado: (2013)

Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL
por: Shi, Chong-Shan, et al.
Publicado: (2019)

Endoplasmic Reticulum–Mitochondrial Ca(2+) Fluxes Underlying Cancer Cell Survival
por: Ivanova, Hristina, et al.
Publicado: (2017)

Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
por: Decuypere, Jean-Paul, et al.
Publicado: (2012)

Domain-specific insight into the recognition of BH3-death motifs by the pro-survival Bcl-2 protein
por: Mushtaq, Ameeq Ul, et al.
Publicado: (2022)

BCL2DB: database of BCL-2 family members and BH3-only proteins
por: Rech de Laval, Valentine, et al.
Publicado: (2014)

BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth
por: Deng, Jiusheng, et al.
Publicado: (2016)

Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax
por: Stehle, Daniel, et al.
Publicado: (2018)

Targeting BCL-2–expressing basal-like breast cancer with BH3-mimetics
por: Oakes, SR, et al.
Publicado: (2012)

BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy
por: Ramesh, Prashanthi, et al.
Publicado: (2020)

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL
por: Thébault, Stéphanie, et al.
Publicado: (2016)

BH3-profiling identifies heterogeneous dependency on Bcl-2 family members in Multiple Myeloma and predicts sensitivity to BH3 mimetics
por: Touzeau, Cyrille, et al.
Publicado: (2015)

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
por: Liu, Qian, et al.
Publicado: (2019)

Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL
por: Ambrosi, Emmanuele, et al.
Publicado: (2011)

Transient Unfolding and Long-Range Interactions in Viral BCL2 M11 Enable Binding to the BECN1 BH3 Domain
por: Ramanathan, Arvind, et al.
Publicado: (2020)

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
por: Rautureau, G J P, et al.
Publicado: (2012)

High pressure polymorphism of LiBH(4) and of NaBH(4)
por: Marizy, Adrien, et al.
Publicado: (2021)

Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction
por: Zhang, Tian-Ying, et al.
Publicado: (2019)

BET-inhibitors as sensitizers for BH3-mimetics
por: Ishida, Chiaki Tsuge, et al.
Publicado: (2017)

The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation
por: Singh, Amandeep, et al.
Publicado: (2018)

Competition Between Phenothiazines and BH3 Peptide for the Binding Site of the Antiapoptotic BCL-2 Protein
por: do Carmo, Aline Lagoeiro, et al.
Publicado: (2020)

Targeting Bcl2 in cancer
por: Chen, Guo, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_i385448iip53so8fk56vhvuecq