Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients

AIMS: Accurate biomarkers for early diagnosis of Alzheimer's disease (AD) are badly needed. Recent reports suggest that dysfunctional mitochondria and DNA damage are associated with AD development. In this report, we measured various cellular parameters, related to mitochondrial bioenergetics a...

Descripción completa

Detalles Bibliográficos
Autores principales: Maynard, Scott, Hejl, Anne-Mette, Dinh, Thuan-Son T., Keijzers, Guido, Hansen, Åse M., Desler, Claus, Moreno-Villanueva, Maria, Bürkle, Alexander, Rasmussen, Lene J., Waldemar, Gunhild, Bohr, Vilhelm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637207/
https://www.ncbi.nlm.nih.gov/pubmed/26539816

Ejemplares similares

Ejemplares similares