Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin

Autophagy controls and executes the turnover of abnormally aggregated proteins. MAP1S interacts with the autophagy marker LC3 and positively regulates autophagy flux. HDAC4 associates with the aggregation-prone mutant huntingtin protein (mHTT) that causes Huntington's disease, and colocalizes w...

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Detalles Bibliográficos
Autores principales: Yue, Fei, Li, Wenjiao, Zou, Jing, Chen, Qi, Xu, Guibin, Huang, Hai, Xu, Zhen, Zhang, Sheng, Gallinari, Paola, Wang, Fen, McKeehan, Wallace L., Liu, Leyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637209/
https://www.ncbi.nlm.nih.gov/pubmed/26540094

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