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Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death
Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on thei...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637302/ https://www.ncbi.nlm.nih.gov/pubmed/26098775 |
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author | Raimondo, Stefania Naselli, Flores Fontana, Simona Monteleone, Francesca Lo Dico, Alessia Saieva, Laura Zito, Giovanni Flugy, Anna Manno, Mauro Di Bella, Maria Antonietta De Leo, Giacomo Alessandro, Riccardo |
author_facet | Raimondo, Stefania Naselli, Flores Fontana, Simona Monteleone, Francesca Lo Dico, Alessia Saieva, Laura Zito, Giovanni Flugy, Anna Manno, Mauro Di Bella, Maria Antonietta De Leo, Giacomo Alessandro, Riccardo |
author_sort | Raimondo, Stefania |
collection | PubMed |
description | Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing. Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment. |
format | Online Article Text |
id | pubmed-4637302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-46373022015-12-02 Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death Raimondo, Stefania Naselli, Flores Fontana, Simona Monteleone, Francesca Lo Dico, Alessia Saieva, Laura Zito, Giovanni Flugy, Anna Manno, Mauro Di Bella, Maria Antonietta De Leo, Giacomo Alessandro, Riccardo Oncotarget Research Paper Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing. Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment. Impact Journals LLC 2015-05-18 /pmc/articles/PMC4637302/ /pubmed/26098775 Text en Copyright: © 2015 Raimondo et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Raimondo, Stefania Naselli, Flores Fontana, Simona Monteleone, Francesca Lo Dico, Alessia Saieva, Laura Zito, Giovanni Flugy, Anna Manno, Mauro Di Bella, Maria Antonietta De Leo, Giacomo Alessandro, Riccardo Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death |
title | Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death |
title_full | Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death |
title_fullStr | Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death |
title_full_unstemmed | Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death |
title_short | Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death |
title_sort | citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress cml xenograft growth by inducing trail-mediated cell death |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637302/ https://www.ncbi.nlm.nih.gov/pubmed/26098775 |
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