FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells

Multiply myeloma (MM) grows in and destroys bone, where osteocytes secrete FGF23, a hormone which affects phosphate homeostasis and aging. We report that multiple myeloma (MM) cells express receptors for and respond to FGF23. FGF23 increased mRNA for EGR1 and its target heparanase, a pro-osteolytic...

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Detalles Bibliográficos
Autores principales: Suvannasankha, Attaya, Tompkins, Douglas R., Edwards, Daniel F., Petyaykina, Katarina V., Crean, Colin D., Fournier, Pierrick G., Parker, Jamie M., Sandusky, George E., Ichikawa, Shoji, Imel, Erik A., Chirgwin, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637311/
https://www.ncbi.nlm.nih.gov/pubmed/25944690

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