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Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms

We recently reported that circulating apolipoprotein AII (apoAII) isoforms apoAII-ATQ/AT (C-terminal truncations of the apoAII homo-dimer) decline significantly in pancreatic cancer and thus might serve as plasma biomarkers for the early detection of this disease. We report here the development of n...

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Autores principales: Honda, Kazufumi, Kobayashi, Michimoto, Okusaka, Takuji, Rinaudo, Jo Ann, Huang, Ying, Marsh, Tracey, Sanada, Mitsuaki, Sasajima, Yoshiyuki, Nakamori, Shoji, Shimahara, Masashi, Ueno, Takaaki, Tsuchida, Akihiko, Sata, Naohiro, Ioka, Tatsuya, Yasunami, Yohichi, Kosuge, Tomoo, Miura, Nami, Kamita, Masahiro, Sakamoto, Takako, Shoji, Hirokazu, Jung, Giman, Srivastava, Sudhir, Yamada, Tesshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637825/
https://www.ncbi.nlm.nih.gov/pubmed/26549697
http://dx.doi.org/10.1038/srep15921
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author Honda, Kazufumi
Kobayashi, Michimoto
Okusaka, Takuji
Rinaudo, Jo Ann
Huang, Ying
Marsh, Tracey
Sanada, Mitsuaki
Sasajima, Yoshiyuki
Nakamori, Shoji
Shimahara, Masashi
Ueno, Takaaki
Tsuchida, Akihiko
Sata, Naohiro
Ioka, Tatsuya
Yasunami, Yohichi
Kosuge, Tomoo
Miura, Nami
Kamita, Masahiro
Sakamoto, Takako
Shoji, Hirokazu
Jung, Giman
Srivastava, Sudhir
Yamada, Tesshi
author_facet Honda, Kazufumi
Kobayashi, Michimoto
Okusaka, Takuji
Rinaudo, Jo Ann
Huang, Ying
Marsh, Tracey
Sanada, Mitsuaki
Sasajima, Yoshiyuki
Nakamori, Shoji
Shimahara, Masashi
Ueno, Takaaki
Tsuchida, Akihiko
Sata, Naohiro
Ioka, Tatsuya
Yasunami, Yohichi
Kosuge, Tomoo
Miura, Nami
Kamita, Masahiro
Sakamoto, Takako
Shoji, Hirokazu
Jung, Giman
Srivastava, Sudhir
Yamada, Tesshi
author_sort Honda, Kazufumi
collection PubMed
description We recently reported that circulating apolipoprotein AII (apoAII) isoforms apoAII-ATQ/AT (C-terminal truncations of the apoAII homo-dimer) decline significantly in pancreatic cancer and thus might serve as plasma biomarkers for the early detection of this disease. We report here the development of novel enzyme-linked immunosorbent assays (ELISAs) for measurement of apoAII-ATQ/AT and their clinical applicability for early detection of pancreatic cancer. Plasma and serum concentrations of apoAII-ATQ/AT were measured in three independent cohorts, which comprised healthy control subjects and patients with pancreatic cancer and gastroenterologic diseases (n = 1156). These cohorts included 151 cases of stage I/II pancreatic cancer. ApoAII-ATQ/AT not only distinguished the early stages of pancreatic cancer from healthy controls but also identified patients at high risk for pancreatic malignancy. AUC values of apoAII-ATQ/AT to detect early stage pancreatic cancer were higher than those of CA19–9 in all independent cohorts. ApoAII-ATQ/AT is a potential biomarker for screening patients for the early stage of pancreatic cancer and identifying patients at risk for pancreatic malignancy (161 words).
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spelling pubmed-46378252015-11-30 Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms Honda, Kazufumi Kobayashi, Michimoto Okusaka, Takuji Rinaudo, Jo Ann Huang, Ying Marsh, Tracey Sanada, Mitsuaki Sasajima, Yoshiyuki Nakamori, Shoji Shimahara, Masashi Ueno, Takaaki Tsuchida, Akihiko Sata, Naohiro Ioka, Tatsuya Yasunami, Yohichi Kosuge, Tomoo Miura, Nami Kamita, Masahiro Sakamoto, Takako Shoji, Hirokazu Jung, Giman Srivastava, Sudhir Yamada, Tesshi Sci Rep Article We recently reported that circulating apolipoprotein AII (apoAII) isoforms apoAII-ATQ/AT (C-terminal truncations of the apoAII homo-dimer) decline significantly in pancreatic cancer and thus might serve as plasma biomarkers for the early detection of this disease. We report here the development of novel enzyme-linked immunosorbent assays (ELISAs) for measurement of apoAII-ATQ/AT and their clinical applicability for early detection of pancreatic cancer. Plasma and serum concentrations of apoAII-ATQ/AT were measured in three independent cohorts, which comprised healthy control subjects and patients with pancreatic cancer and gastroenterologic diseases (n = 1156). These cohorts included 151 cases of stage I/II pancreatic cancer. ApoAII-ATQ/AT not only distinguished the early stages of pancreatic cancer from healthy controls but also identified patients at high risk for pancreatic malignancy. AUC values of apoAII-ATQ/AT to detect early stage pancreatic cancer were higher than those of CA19–9 in all independent cohorts. ApoAII-ATQ/AT is a potential biomarker for screening patients for the early stage of pancreatic cancer and identifying patients at risk for pancreatic malignancy (161 words). Nature Publishing Group 2015-11-09 /pmc/articles/PMC4637825/ /pubmed/26549697 http://dx.doi.org/10.1038/srep15921 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Honda, Kazufumi
Kobayashi, Michimoto
Okusaka, Takuji
Rinaudo, Jo Ann
Huang, Ying
Marsh, Tracey
Sanada, Mitsuaki
Sasajima, Yoshiyuki
Nakamori, Shoji
Shimahara, Masashi
Ueno, Takaaki
Tsuchida, Akihiko
Sata, Naohiro
Ioka, Tatsuya
Yasunami, Yohichi
Kosuge, Tomoo
Miura, Nami
Kamita, Masahiro
Sakamoto, Takako
Shoji, Hirokazu
Jung, Giman
Srivastava, Sudhir
Yamada, Tesshi
Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms
title Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms
title_full Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms
title_fullStr Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms
title_full_unstemmed Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms
title_short Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms
title_sort plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-aii isoforms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637825/
https://www.ncbi.nlm.nih.gov/pubmed/26549697
http://dx.doi.org/10.1038/srep15921
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