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LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration

The Liver Kinase B1 (LKB1) gene plays crucial roles in cell differentiation, proliferation and the establishment of cell polarity. We created LKB1 conditional knockout mice (LKB1(Atoh1) CKO) to investigate the function of LKB1 in cerebellar development. The LKB1(Atoh1) CKO mice displayed motor dysfu...

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Detalles Bibliográficos
Autores principales:	Men, Yuqin, Zhang, Aizhen, Li, Haixiang, Jin, Yecheng, Sun, Xiaoyang, Li, Huashun, Gao, Jiangang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637891/ https://www.ncbi.nlm.nih.gov/pubmed/26549569 http://dx.doi.org/10.1038/srep16232

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