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Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2)

The ability of the anti-diabetic drug metformin to inhibit anabolic processes including gluconeogenesis and lipogenesis is partly attributable to activation of the AMP-activated protein kinase (AMPK) pathway. The p160 steroid receptor coactivator 2 (SRC-2) is a key regulator of cellular metabolism a...

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Detalles Bibliográficos
Autores principales:	Madsen, Andre, Bozickovic, Olivera, Bjune, Jan-Inge, Mellgren, Gunnar, Sagen, Jørn V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637908/ https://www.ncbi.nlm.nih.gov/pubmed/26548416 http://dx.doi.org/10.1038/srep16430

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