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Influence of the proton pump inhibitor lansoprazole on distribution and activity of doxorubicin in solid tumors

Cellular causes of resistance and limited drug distribution within solid tumors limit therapeutic efficacy of anticancer drugs. Acidic endosomes in cancer cells mediate autophagy, which facilitates survival of stressed cells, and may contribute to drug resistance. Basic drugs (e.g. doxorubicin) are...

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Detalles Bibliográficos
Autores principales:	Yu, Man, Lee, Carol, Wang, Marina, Tannock, Ian F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638015/ https://www.ncbi.nlm.nih.gov/pubmed/26212113 http://dx.doi.org/10.1111/cas.12756

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