Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons

BACKGROUND: β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is a membrane-bound aspartyl protease that initiates amyloid β-protein (Aβ) generation. Aberrant elevation of BACE1 levels in brains of Alzheimer’s disease (AD) patients may involve Aβ. In the present study, we used a neuron cult...

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Detalles Bibliográficos
Autores principales: Mamada, Naomi, Tanokashira, Daisuke, Hosaka, Ai, Kametani, Fuyuki, Tamaoka, Akira, Araki, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638102/
https://www.ncbi.nlm.nih.gov/pubmed/26552445
http://dx.doi.org/10.1186/s13041-015-0163-5

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