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Diversity of CRISPR-Cas immune systems and molecular machines
Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638107/ https://www.ncbi.nlm.nih.gov/pubmed/26549499 http://dx.doi.org/10.1186/s13059-015-0816-9 |
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| author | Barrangou, Rodolphe |
| author_facet | Barrangou, Rodolphe |
| author_sort | Barrangou, Rodolphe |
| collection | PubMed |
| description | Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications. |
| format | Online Article Text |
| id | pubmed-4638107 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46381072015-11-10 Diversity of CRISPR-Cas immune systems and molecular machines Barrangou, Rodolphe Genome Biol Review Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications. BioMed Central 2015-11-09 2015 /pmc/articles/PMC4638107/ /pubmed/26549499 http://dx.doi.org/10.1186/s13059-015-0816-9 Text en © Barrangou. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Review Barrangou, Rodolphe Diversity of CRISPR-Cas immune systems and molecular machines |
| title | Diversity of CRISPR-Cas immune systems and molecular machines |
| title_full | Diversity of CRISPR-Cas immune systems and molecular machines |
| title_fullStr | Diversity of CRISPR-Cas immune systems and molecular machines |
| title_full_unstemmed | Diversity of CRISPR-Cas immune systems and molecular machines |
| title_short | Diversity of CRISPR-Cas immune systems and molecular machines |
| title_sort | diversity of crispr-cas immune systems and molecular machines |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638107/ https://www.ncbi.nlm.nih.gov/pubmed/26549499 http://dx.doi.org/10.1186/s13059-015-0816-9 |
| work_keys_str_mv | AT barrangourodolphe diversityofcrisprcasimmunesystemsandmolecularmachines |