Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy

The aging myopathy manifests itself with diastolic dysfunction and preserved ejection fraction. We raised the possibility that, in a mouse model of physiological aging, defects in electromechanical properties of cardiomyocytes are important determinants of the diastolic characteristics of the myocar...

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Detalles Bibliográficos
Autores principales: Signore, Sergio, Sorrentino, Andrea, Borghetti, Giulia, Cannata, Antonio, Meo, Marianna, Zhou, Yu, Kannappan, Ramaswamy, Pasqualini, Francesco, O'Malley, Heather, Sundman, Mark, Tsigkas, Nikolaos, Zhang, Eric, Arranto, Christian, Mangiaracina, Chiara, Isobe, Kazuya, Sena, Brena F., Kim, Junghyun, Goichberg, Polina, Nahrendorf, Matthias, Isom, Lori L., Leri, Annarosa, Anversa, Piero, Rota, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638135/
https://www.ncbi.nlm.nih.gov/pubmed/26541940
http://dx.doi.org/10.1038/ncomms9803

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